Inorganic Lead Exposure: Metabolism and Intoxication offers a comprehensive review of the evolution of scientific knowledge and the current state of the art in relation to lead interaction with the environment and the mammalian body. The authors focus on the sources of lead pollution to which humans are exposed during daily and working life, and on lead uptake, distribution, and excretion, clarifying our knowledge of the toxicity of this metal. They also provide a highly detailed description of saturnism and a thorough analysis of its critical effects on target organs.
Introduction. The History of Lead Poisoning and Uses of Lead over the Centuries. Lead Exposure (N. Sannolo, G. Carelli, N. Castellino, and G. De Lorenzo): Exposure. Lead Metabolism (N. Castellino, P. Castellino, N. Sannolo, O. Masci, G. Fabri, L. Bologna, and R. Bongarzone): General Overview. Lead Intoxication (P. Castellino, N. Castellino, G. Fabri, O. Mattei, V. Anzelmo, P. Bianco, L. Bologna, D. Chiari, G. De Lorenzo, G. Sabatelli, F. Sabella, and A. Sacco): Clinical Presentation of Human Lead Poisoning. The Neurologic Toxicity of Lead. Lead and the Kidney. Lead and the Erythropoietic System. Lead and the Cardiovascular System. Gastrointestinal and Hepatic Effects of Lead. Lead and the Reproductive System. Lead and the Endocrine System. Immunologic Aspects of Lead Poisoning. Lead Carcinogenicity. Prevention. (N. Castellino, P. Castellino, A.M. Alimandi, and L. Bologna). Lead Exposure During Fetal Life and Childhood. Unusual Sources of Non-Occupational Plumbism.