This book explores the important role of the interferons in infections due to nonviral intracellular pathogens. It deals with the induction of interferons by a variety of intracellular microorganisms and the effects of interferons on the host cells and the microorganisms.
Part I: The Interferon System 1. Interferons and Their Induction 2. Interferons and Their Mechanisms of Action Part II: Obligate Intracellular Pathogens 3. Interferons, Immunity, and Chlamydiae 4. Chlamydia trachomatis Growth Inhibition by IFNγ: Implications for Persistent Chlamydial Infections 5. Interactions Between Rickettsia prowazekii and Cultured Host Cells: Alterations Induced by Gamma Interferon 6. IFNγ as an Effector Molecule in Antirickettsial Immunity 7. Toxoplasma 8. Toxoplasma gondii 9. Leishmania 10. Modulatory Effects of Interferons on Trypanosoma cruzi Infections 11. Enhancement of Resistance to Trypanosoma cruzi Infection by Recombinant IFN7 12. Antimalarial Activity of IFNγ: Requirement for Immunity to Sporozoite Challenge Part III: Facultative Intracellular Pathogens 13. Induction and Possible Functions of Interferons During Murine Listeriosis 14. Role of Interferon in Immunity to Mycobacteria 15. Legionella pneumophila 16. Interferon Effects on Infection with Enteroinvasive Bacteria