Intraperitoneal Cancer Therapy : Principles and Practice book cover
1st Edition

Intraperitoneal Cancer Therapy
Principles and Practice

ISBN 9781482261189
Published December 9, 2015 by CRC Press
411 Pages - 88 Color Illustrations

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Book Description

Intraperitoneal Cancer Therapy: Principles and Practice is one of the first books to combine the latest clinical developments in the treatment of patients with peritoneal surface disease and the scientific principles that underlie the concept of intraperitoneal cancer therapy.

The book covers basic concepts such as anatomy, physiology, pharmacology, and mathematical models of drug transport as well as practical clinical applications, highlighted with results from clinical trials and promising novel preclinical developments.

The book is a state-of-the-art reference for surgical and medical oncologists interested in the treatment of carcinomatosis. It also establishes and promotes basic and translational research interest in the field of intraperitoneal drug delivery, which has the potential to improve the outcome for this dreaded condition. Edited by two renowned surgical oncologists, it represents the definitive reference in the field of intraperitoneal cancer therapy.

Table of Contents


Embryology and Anatomy of the Peritoneal Cavity

Jesus Esquivel

Structure and Function of the Mesothelial Cell

Steven E. Mutsaers, Cecilia M. Prêle, and Sarah E. Herrick

Applied Radiological Anatomy of the Peritoneal Cavity

Katie Planche

Peritoneal Drug Transport

Michael F. Flessner


Molecular Biology of Peritoneal Carcinomatosis

Riom Kwakman, Nina R. Sluiter, Erienne M.V. de Cuba, and Elisabeth (Lisette) A. te Velde

Dissemination and Adhesion of Peritoneal Cancer Cells to the Peritoneal Wall

Elly De Vlieghere, Marc Bracke, Laurine Verset, Pieter Demetter, and Olivier De Wever

Genomic Approaches to Peritoneal Carcinomatosis

Haroon A. Choudry and David L. Bartlett

Surgery, Wound Healing, and Peritoneal Minimal Residual Disease in Colorectal Cancer

Wim P. Ceelen

Role of the Greater Omentum in the Pathogenesis of Peritoneal Carcinomatosis

Manuel J. Koppe

Lymphatic Transport and the Diaphragmatic Stomata

Katharina G.M.A. D’Herde


Pharmacokinetics of Intraperitoneal Cytotoxic Drug Therapy

Kurt Van der Speeten

Tissue Transport and Pharmacodynamics of Intraperitoneal Chemotherapy

Pieter Colin, Félix Gremonprez, and Wim P. Ceelen

Mathematical Models of Intraperitoneal Drug Delivery

Joanna Stachowska-Pietka and Jacek Waniewski


Management of Peritoneal Metastases Using Cytoreductive Surgery and Perioperative Chemotherapy

Paul H. Sugarbaker

Chemoperfusion Techniques and Technologies

Kiran Turaga

Port Placement for Intraperitoneal Chemotherapy

Lisa M. Landrum and Joan L. Walker


Intraperitoneal Chemotherapy for Ovarian Cancer

Abdulrahman Sinno and Deborah Armstrong

Cytoreductive Surgery and HIPEC in the Treatment of Advanced Epithelial Ovarian Cancer and Serous Papillary Peritoneal Carcinoma

Deraco Marcello, Kusamura Shigeki, and Baratti Dario

Pseudomyxoma Peritonei

Bettina Lieske and Brendan Moran

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Metastatic Colorectal Cancer with Peritoneal Surface Disease

Edward A. Levine and Chukwuemeka Obiora

Diffuse Malignant Peritoneal Mesothelioma: Current Concepts in Evaluation and Management

Keli M. Turner and H. Richard Alexander, Jr

Gastric Cancer and Intraperitoneal Chemotherapy

Valerie Francescutti, John M. Kane III, and Joseph J. Skitzki

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Small Bowel Adenocarcinoma

Edward A. Levine

Peritoneal Surface Malignancy from Neuroendocrine Tumors

Mladjan Protic, Itzhak Avital, and Alexander Stojadinovic

Treatment Considerations for High-Grade Appendiceal Adenocarcinoma

Sean P. Dineen, Melissa Taggart, Richard E. Royal, Paul Mansfield, and Keith F. Fournier

Systemic Therapy for Appendiceal Cancer

Jennifer L. Zadlo and Cathy Eng

Toxicity and Morbidity of IP Drug Therapy

Colette Pameijer

Safety Considerations and Occupational Hazards

Joel M. Baumgartner, Kaitlyn J. Kelly, and Andrew M. Lowy

Role of CRS/HIPEC in the Management of Malignant Ascites

Konstantinos I. Votanopoulos


Development of Drug-Loaded Particles for Intraperitoneal Therapy

Ze Lu, M. Guillaume Wientjes, and Jessie L.-S. Au

Biomaterials and Drug Delivery Systems for Intraperitoneal Chemotherapy

Bo Sun and Yoon Yeo

Intraperitoneal Nonviral Nucleic Acid Delivery in the Treatment of Peritoneal Cancer

George R. Dakwar, Stefaan S.C. De Smedt, and Katrien Remaut

Immunotherapy of Peritoneal Carcinomatosis

Michael A. Ströhlein and Markus M. Heiss

The Promise of Oncolytic Viral Therapy for the Treatment of Peritoneal Surface Malignancies

John H. Stewart, IV and Lauren Gillory

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)

Marc A. Reymond, W. Solass, and C. Tempfer

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Edited by

Wim P. Ceelen, MD, PhD, professor of surgery, Ghent University Hospital, Belgium

Edward Levine, MD, professor of surgery and chief of surgical oncology, Wake Forest University, Winston-Salem, USA


"The unique feature of this book is its complete coverage of all essentials for treating peritoneal surface malignancies -- it is truly a "one stop shop"… The quality of this book is superb and the digital version provides an extra dimension. It is unique in the comprehensive coverage of this highly specific topic and cannot readily be compared to other books." - Carlos HF Chan, MD, PhD (University of Iowa Hospitals and Clinics), 5 stars, Doody Enterprises