Introduction to In Vitro Cytotoxicology: Mechanisms and Methods, 1st Edition (e-Book) book cover

Introduction to In Vitro Cytotoxicology

Mechanisms and Methods, 1st Edition

By Frank A. Barile

CRC Press

240 pages

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First Published in 1994, Introduction to In Vitro Cytotoxicology examines in vitro cytotoxicology, which offers new methodologies to toxicity testing. This important new discipline of modern toxicology is gaining increased acceptance as a viable alternative to traditional testing methods. The text discusses the application of in vitro cytotoxicology to toxicity testing and human risk assessment, and it analyzes the advantages and limitations of the tests performed under scientific and regulatory conditions. The book also reviews the optimum utilization of certain tests for specific groups of chemicals relevant to validation programs currently in progress. This book is a useful reference tool for students, researchers, and practitioners interested in academic, industrial, and regulatory toxicology; environmental health; cell biology; pharmacology; dentistry; or human and veterinary medicine.


"This excellent little book truly lives up to its title, and I strongly recommend it as a book that should be in every in vitro toxicology laboratory. Those with experience in the field will be able to say that it will be useful for their new students, but the wiser among them will into it and admit that it provides many new ideas and insights."

Michael Balls, As Quoted in the Journal Alternatives to Laboratory Animals

Volume 22, No. 5, September/October 1994

Table of Contents

Cell Culture Methodology and Its Application to In Vitro Cytotoxicology

Mechanisms of Cytotoxicology

Cellular Methods of General Toxicity

Cellular Methods of Target-Organ Toxicity

Cellular Methods of Local Toxicity

Cellular Methods of Teratogenicity

Cellular Methods of Immune Function

Pharmacokinetic Studies in Cellular Systems

Cellular Methods of Genotoxicity and Carcinogenicity, T.W. Sawyer

Experimental Design and Statistics

Standardization and Validation, B. Ekwall, F.A. Barile

Cell Culture or Animal Toxicity Tests? Or Both?


About the Author

Frank A. Barile

About the Series

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Toxicology
SCIENCE / Research & Methodology