First Published in 1994, Introduction to In Vitro Cytotoxicology examines in vitro cytotoxicology, which offers new methodologies to toxicity testing. This important new discipline of modern toxicology is gaining increased acceptance as a viable alternative to traditional testing methods. The text discusses the application of in vitro cytotoxicology to toxicity testing and human risk assessment, and it analyzes the advantages and limitations of the tests performed under scientific and regulatory conditions. The book also reviews the optimum utilization of certain tests for specific groups of chemicals relevant to validation programs currently in progress. This book is a useful reference tool for students, researchers, and practitioners interested in academic, industrial, and regulatory toxicology; environmental health; cell biology; pharmacology; dentistry; or human and veterinary medicine.
Table of Contents
Cell Culture Methodology and Its Application to In Vitro Cytotoxicology
Mechanisms of Cytotoxicology
Cellular Methods of General Toxicity
Cellular Methods of Target-Organ Toxicity
Cellular Methods of Local Toxicity
Cellular Methods of Teratogenicity
Cellular Methods of Immune Function
Pharmacokinetic Studies in Cellular Systems
Cellular Methods of Genotoxicity and Carcinogenicity, T.W. Sawyer
Experimental Design and Statistics
Standardization and Validation, B. Ekwall, F.A. Barile
Cell Culture or Animal Toxicity Tests? Or Both?
Frank A. Barile
"This excellent little book truly lives up to its title, and I strongly recommend it as a book that should be in every in vitro toxicology laboratory. Those with experience in the field will be able to say that it will be useful for their new students, but the wiser among them will into it and admit that it provides many new ideas and insights."
Michael Balls, As Quoted in the Journal Alternatives to Laboratory Animals
Volume 22, No. 5, September/October 1994