As the tools and techniques of structural biophysics assume greater roles in biological research and a range of application areas, learning how proteins behave becomes crucial to understanding their connection to the most basic and important aspects of life.
With more than 350 color images throughout, Introduction to Proteins: Structure, Function, and Motion presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural–biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules.
The text incorporates various biochemical, physical, functional, and medical aspects. It covers different levels of protein structure, current methods for structure determination, energetics of protein structure, protein folding and folded state dynamics, and the functions of intrinsically unstructured proteins. The authors also clarify the structure–function relationship of proteins by presenting the principles of protein action in the form of guidelines.
This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. It refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. Downloadable questions for each chapter are available at CRC Press Online.
Table of Contents
THE IMPORTANCE OF PROTEINS IN LIVING ORGANISMS
STRUCTURAL COMPLEXITY AND ITS EFFECT ON PROTEIN FUNCTION
NON-COVALENT INTERACTIONS BETWEEN ATOMS IN BIOMOLECULES
Methods of Structure Determination and Prediction
COMPUTATIONAL METHODS FOR STRUCTURE PREDICTION
THE PROTEIN DATA BANK (PDB)
Energetics and Protein Stability
BASIC PRINCIPLES OF THERMODYNAMICS
PROTEIN STABILITY AND THE FORCES INVOLVED
PROTEIN DENATURATION AND ADAPTATION TO EXTREME CONDITIONS
STABILITY ENHANCEMENT OF INDUSTRIAL ENZYMES USING PROTEIN ENGINEERING
Protein Structural Dynamics
FOLDED STATE DYNAMICS
METHODS FOR STUDYING PROTEIN DYNAMICS
INTRINSICALLY UNSTRUCTURED PROTEINS
STRUCTURE AND ORGANIZATION OF BIOLOGICAL MEMBRANES
PRINCIPLES OF MEMBRANE PROTEIN STRUCTURE
STRUCTURE–FUNCTION RELATIONSHIP IN MEMBRANE PROTEINS AND PEPTIDES
THEORIES ON PROTEIN–LIGAND BINDING
PROTEIN–LIGAND BINDING ENERGETICS
THE LIGAND-BINDING SITE
PROTEIN–LIGAND INTERACTIONS IN DRUG ACTION AND DESIGN
A Summary and References appear at the end of each chapter.
Amit Kessel is co-founder of Es-is Technologies Ltd., which designs biocatalysts for the pharmaceutical industry. He also teaches protein biochemistry and biophysics at the Tel Aviv-Yaffo Academic College. During his postdoctoral research at Columbia University, Dr. Kessel focused on various physicochemical aspects of protein–protein interactions at the molecular level.
Nir Ben-Tal is a professor in the Department of Biochemistry and Molecular Biology at Tel-Aviv University. His research in computational biology has involved predicting the three-dimensional structures of transmembrane proteins and developing the ConSurf web server for the detection of functional regions by mapping evolutionary data on protein structures.
"I’ve just lately used this textbook for a presentation on electrostatics. Although I have an organic background, I discovered that the explanations of electrostatic interactions are very clear and informative. The language isn’t too technical and may be easily understood by biology students. The textbook covers numerous examples and colorful illustrations, which made it easy to understand the principles discussed. The book is well organized in chapters for all the fundamental topics. I feel this book would be appropriate for any undergraduate and graduate scholar who’s keen on proteins. … It’s complete, easy to observe and (something I at least discover uncommon for textbooks) pleasing to read. The authors don’t shrink back from any subjects, but clarify things in a straightforward method supported by ample examples. Highly recommended."
—Physics Book Reviews at dowdawgs.com, May 2013
Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. …The book is clear, well organized, aptly illustrated in color, and a pleasure to read. The first two chapters are an impressive textbook unto themselves … The book is thoroughly documented with citations to the literature gathered at the end of each chapter. … Overall, this is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field.
—Eric Martz, Biochemistry and Molecular Biology Education, Vol. 40, 2012
This is an important book. … This book captures in a very accessible way a growing body of literature on the structure, function and motion of proteins, and links this to more established paradigms such as a reader might find in a mainstream biochemistry text. … The text is littered with excellent examples of the wider relevance of the material covered … . The book is exceptionally well written … I learned new things from each chapter. … a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers and instructors involved in structural biology or biophysics courses or in research on protein structure–function relationships. I would recommend it highly.
—David Sheehan, ChemBioChem, 2011
The book by Kessel and Ben-Tal offers a unique combination of structure, thermodynamics and biology. I was impressed both by the breadth of the topics covered and by the depth in which they are treated. General principles are made intuitively clear based on well-chosen examples, many of them having relevance to disease. The book could fit well as a textbook in structural biology and molecular biophysics courses.
—Barry Honig, Columbia University, New York, New York, USA
… the book provides general guidelines for understanding protein structure and demonstrates how we can use the structure to phrase testable hypotheses about biological function. … The repeated use of the same example makes it easier for the reader to grasp the general principles. The book gives a coherent picture of each topic … [and] includes ample references, making it possible for the interested reader to dig deeply into various topics. The book also covers structural aspects of intrinsically unstructured proteins and how this property facilitates their biological function. … The book provides background in cell biology, basic chemistry and thermodynamics, making it useful for newcomers to the protein structure field who want to catch up quickly. … it [is also] easy for experts to dive into the more specialized aspects quickly. … The book provides references to user-friendly web tools in the field. The publisher’s website provides exercises on both theory and practice. Sample solutions and PowerPoint presentations are available for qualified teachers. These make the book attractive as the main textbook in an undergraduate course on protein structure. Perhaps also for parts of freshman biochemistry. … useful as supplement for many undergraduate and graduate courses.
—Burkhard Rost, Technische Universität München, Germany