Investigative Immunotoxicology: 1st Edition (Hardback) book cover

Investigative Immunotoxicology

1st Edition

Edited by Helen Tryphonas, Michel Fournier, Barry R. Blakley, Judit Smits, Pauline Brousseau

CRC Press

480 pages | 5 Color Illus. | 58 B/W Illus.

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Hardback: 9780415308540
pub: 2005-01-27
$165.00
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Description

Investigative Immunotoxicology provides a critical evaluation of proposed experimental animal models and approaches, and discusses the contribution that immunotoxicity can make to the overall assessment of chemical-induced adverse health effects on humans and the ecosystem. Following a review of general concepts in immunotoxicology, the book discusses emerging methodologies at the cellular and molecular levels, and describes advances in and requirements for animal model development in testing the allergenicity of foods and genetically modified products. It presents animal models of autoimmunity associated with chemical exposure, includes recommendations for the selection of sentinel species in ecotoxicology, and presents an in-depth review of immunotoxicology as it relates to a variety of wildlife species. Finally, the book explains the role of immunotoxicology in human health risk assessment and the regulatory process.

Outlining the potential chemical hazards facing human and ecosystem health, this is a valuable reference for professionals and researchers in immunotoxicology and risk assessment. It also deserves the attention of the pharmaceutical industry and environmental toxicologists who are concerned about the effects of xenobiotics on ecosystems.

Table of Contents

SECTION I. THE IMMUNE SYSTEM

Structural and Functional Complexity of the Immune System and its Relationship to Immunotoxicology, Barry R. Blakey and Edward Kouassi

SECTION II. APPROACHES AND MODELS RELEVANT TO THE ASSESSMENT OF CHEMICAL-INDUCED IMMUNOTOXIC EFFECTS IN THE ECOSYSTEM

Ecoimmunotoxicology: State of the Science, Michael R. Woolhiser, Kevin S. Henry, and Michael P. Holsapple

Bivalves as Models for Marine Immunotoxicology, Michael Auffrett

Approaches and Models for the Assessment of Chemical-Induced Immunotoxicity in Fish, Jessica E. Duffy and Judith T. Zelikoff

Immunotoxicology in Marine Mammals, Sylvain de Guise

Amphibian Models and Approaches to Immunotoxicology, Louise A. Rollins-Smith and Judit E.G. Smits

Earthworms as Ecosentinels for Chemical-Induced Immunotoxicology, Arthur J. Goven, Barney J. Venables, and Lloyd C. Fitzpatrick

Reptiles: The Research Potential of an Overlooked Taxon in Immunotoxicology, Andrew A. Rooney

Immunotoxicology in Terrestrial Wildlife, Judy Smits and David Janz

Immune Markers in Ecotoxicology: A Comparison Across Species, Harri Salo, Claire Dautremepuits, Judit Smis, Pauline Brousseau, and Michael Fournier

SECTION III: APPROACHES AND MODELS RELEVANT TO THE ASSESSMENT OF THE IMPACT OF CHEMICAL-INDUCED IMMUNOTOXICITY ON HUMAN HEALTH

Are Changes in the Immune System Predictive of Clinical Diseases?, Michael I. Luster, Dori R. Germolec, Christine G. Parks, Laura Blanciforti, Michael Kashon, and Robert Luebke

Developmental Immunotoxicology in Rodent Species, Barry R. Blakley and Patrcia M. Blakley

Gut Mucosal Immunotoxicology In Rodents, Genevieve S. Bondy and James J. Pestka

The Use of Old World Nonhuman Primates as Models for Evaluating Chemical-Induced Alterations of the Immune System, Helen Tryphonas and Douglas L. Arnold

Practical Considerations for Toxicologic Pathology Assessment of the Immune System in Rodents and Nonhuman Primates, Olga Pulido, Don Caldwell, Meghan Murphy, and Santokh Gill

Approaches to Immunotoxicology in Human Population Studies, Frédéric Dallaire, É ric Dewailly, and Pieree Ayotte

SECTION IV: MODELS AND APPROACHES TO CHEMMICAL-INDUCED ALLERGENICITY

Guinea Pig, Mouse, and Rat Models for the Safety Assessment of Protein Allergenicity, Katherine Sarlo, Rebecca J. Dearman, and Ian Kimber

Hypersensitivity Reactions: Nonrodent Animal Models, Ricki M. Helm

Recent Developments in Allergic Contact Dermatitis, Ian Kimber and Rebecca J. Dearman

Predictive Methods Specific for Human Immune Response, Fiona A. Harding, David Wong, and Donald P. Naki

SECTION V: AUTOIMMUNITY

Chemical-Induced Animal Models of Human Autoimmunity, Pierluigi E. Bigazzi

SECTION VI: EMERGING ISSUES IN IMMUNOTOXICOLOGY

Transgenic Rodent Mice in Immunotoxicology, Robert V. House

Applications of Genomics in Immunotoxicology, Sami Haddad, Michele D'Elia, Jacques Bernier, Alain Fournier, and Daniel G. Cyr

SECTION VII: THE ROLE OF IMMUNOTOXICOLOGY IN RISK ASSESSMENT AND THE REGULATORY PROCESS

Biomarkers of Immunotoxic Effects in the Context of Environmental Risk Assessment, Stépane Pillet and Jean-Marc Nicolas

Toxicological Considerations: Making the Connection Between Toxicologic and Immunotoxicologic Studies as These Relate to Human and Ecosystem Health, Michel Fournier, Barry R. Blakley, Herman J. Boermans, and Pauline Brousseau

Approaches to Immunotoxicity Testing: The Need for National and International Harmonization/Standardization of Immunotoxicity Methods, Pauline Brousseau, Barry R. Blakley, Herman J. Boermans, and Michel Fournier

Approaches to the Statistical Analysis of Immunotoxicologic Data in Support of Risk Assessment, Stephen Hayward

Subject Categories

BISAC Subject Codes/Headings:
MED044000
MEDICAL / Immunology
MED096000
MEDICAL / Toxicology