Ion and Molecule Transport in Lysosomes  book cover
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Ion and Molecule Transport in Lysosomes




ISBN 9781138560390
Published June 2, 2020 by CRC Press
251 Pages 24 Color & 8 B/W Illustrations

 
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Book Description

Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters.

Key selling features:

  • Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal
  • Reviews essential cellular functions of lysosomes
  • Explores how lysosome dysfunction is the cause of many metabolic disorders
  • Examines how lysomes are involved in storage diseases
  • Describes various technologies and methods used in lysosome research
  • Table of Contents

    Preface

    Editors

    Contributors

    1. Endosomal and Lysosomal Electrophysiology

    Xiaoli Zhang, Mingxue Gu, Meiqin Hu, Yexin Yang, and Haoxing Xu

    2. Chloride Transport across the Lysosomal Membrane

    Sonali Saha, Anja Blessing, and Thomas J. Jentsch

    3. Endolysosomal Patch Clamping: Approaches to Measure Vesicular Ion Channel Activities

    Cheng-Chang Chen, Christian Grimm, Christian Wahl-Schott and Martin Biel

    4. TRPML Subfamily of Endolysosomal Channels: Concepts and Methods

    Nicholas E. Karagas, Morgan A. Rousseau, and Kartik Venkatachalam

    5. Investigating the Role of Two-Pore Channel 2 (TPC2) in Zebrafish Neuromuscular Development

    Sarah E. Webb, Jeffrey J. Kelu, and Andrew L. Miller

    6. Functional Study of Lysosomal Nutrient Transporters

    Xavier Leray, Corinne Sagné, and Bruno Gasnier

    7. Lysosomal Vitamin B12 Trafficking

    Sean Froese and Matthias R. Baumgartner

    8. Detection of Lysosomal Membrane Permeabilization

    Anne-Marie Ellegaard, Line Groth-Pedersen, and Marja Jäättelä

    9. Rapid Isolation of Lysosomes from Cultured Cells Using a Twin Strep Tag

    Jian Xiong, Jingquan He, Michael X. Zhu, and Guangwei Du

    10. A Transcriptomic Analysis and shRNA Screen for Intracellular Ion Channels and Transporters Regulating Pigmentation

    Donald C. Koroma, Salwa Y. Hafez, and Elena Oancea

    Index

    ...
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    Editor(s)

    Biography

    Bruno Gasnier is CNRS Research Director, Group Leader at CNRS/Paris Descartes.

    Michael Xi Zhu is currently with the Department of Integrative Biology and Pharmacology at the University of Texas Health Science Center at Houston.