Ion and Molecule Transport in Lysosomes: 1st Edition (Hardback) book cover

Ion and Molecule Transport in Lysosomes

1st Edition

Edited by Bruno Gasnier, Michael X. Zhu

CRC Press

264 pages | 24 Color Illus. | 8 B/W Illus.

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Hardback: 9781138560390
pub: 2020-06-05
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Description

Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters.

Key selling features:

  • Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal
  • Reviews essential cellular functions of lysosomes
  • Explores how lysosome dysfunction is the cause of many metabolic disorders
  • Examines how lysomes are involved in storage diseases
  • Describes various technologies and methods used in lysosome research
  • Table of Contents

    Electrophysiological recording of endolysosomal channels. Endolysosmal two-pore channels and their regulation by mechanistic target of rapamycin (mTOR). Chloride transport across the lysosomal membrane. Mucolipin channels in lysosome storage disease. Ion channels of melanosomes and melanin formation. NAADP-mediated lysosomal Ca2+ release and NAADP receptors. Endolysosomal channels critical for endolysotosis and recycling. Mechanism of Ebola virus invasion via endocytic pathway and lysosome escape. The lysosomal H+ ATPase. Amino acid transport across the lysosomal membrane. Amino acid sensing at the lysosomal membrane. Cholesterol transport across the lysosomal membrane. Lysosomal peptide translocation. Chaperonemediated autophagy. Lysosomal membrane permeabilization.

    About the Editors

    Bruno Gasnier is CNRS Research Director, Group Leader at CNRS/Paris Descartes.

    Michael Xi Zhu is currently with the Department of Integrative Biology and Pharmacology at the University of Texas Health Science Center at Houston.

    About the Series

    Methods in Signal Transduction Series

    Learn more…

    Subject Categories

    BISAC Subject Codes/Headings:
    MED005000
    MEDICAL / Anatomy
    SCI017000
    SCIENCE / Life Sciences / Cytology
    SCI049000
    SCIENCE / Life Sciences / Biology / Molecular Biology
    SCI086000
    SCIENCE / Life Sciences / General