Jak-STAT Signaling in Diseases: 1st Edition (Hardback) book cover

Jak-STAT Signaling in Diseases

1st Edition

Edited by Ritobrata Goswami

CRC Press

296 pages | 21 Color Illus. | 13 B/W Illus.

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Hardback: 9781138487628
pub: 2020-02-24
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Description

JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis.

Features:

  • Details activation and microRNA-mediated regulation of JAK-STAT pathway
  • Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe
  • Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway.

An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.

Table of Contents

Regulation of cytokine signaling by the JAK-STAT pathway

Nicolette N Houreld

The structure-function bonhomie of JAK/STAT molecules

Ritobrata Goswami

MicroRNA-mediated Regulation of JAK-STAT Signaling in Non-Cancerous Human Diseases

Chandra S. Boosani, Wanlin Jiang, Taylor Burke and Devendra K. Agrawal

JAK-STAT signaling in asthma and allergic airway inflammation

Amina Abdul Qayum, Tristan Hayes and Mark H. Kaplan

Role of JAK-STAT signaling in atopic dermatitis

Radomir M. Slominski and Matthew J. Turner

JAK/STAT signalling pathway and gliosis in neuroinflammatory diseases

Han-Chung Lee, Kai-Leng Tan, Pike-See Cheah and King-Hwa Ling

Jak-STAT Signaling in Cardiovascular Disease

George W. Booz, Raffaele Altara and Sean P. Didion

Diabetes and Obesity: Abnormal Jak-STAT signaling

Marcia J. Abbott

Jak-STAT signaling in Liver Fibrosis

Marwa K. Ibrahim and Noha G. Bader El Din

Renal disorders: Involvement of Jak-STAT pathway

Yuji Nozaki

JAK-STAT signaling in hematologic malignancies

Thomas Pincez and Thai Hoa Tran

Aberrant JAK-STAT signaling in Hematopoietic Malignancies

Parvis Sadjadian

Immunodeficiency: Consequences of mutations in Jak-STAT signaling

Daniel Silberger and Duy Pham

Targeting Jak-STAT pathway for various inflammatory diseases and viral infections

Christina Gavegnano and Raymond F. Schinazi

About the Editor

Ritobrata Goswami, PhD is presently working as an Assistant Professor in the School of Bioscince, IIT Kharagpur since 2016. Prior to his present affiliation, Dr Goswami was associated in the Division of Biological and Life Sciences, Ahmedabad University (2014-16). He received his bachelor (2005) and masters degree (2007) in Biotechnology from West Bengal University of Technology and Birla Institute of Technology & Science, Pilani; respectively. Dr Goswami obtained his PhD at Indiana University, Indianpolis, USA (2012) followed by post-doctoral training at Icahn School of Medicine at Mount Sinai, New York, USA (2012-14). He is a life member of the Indian Immunology Society. Dr Goswami has extramural projects funded by the Government of India. Dr Goswami’s research interests include the role of nutrients and hormones in the development and function of T helper cells to regulate inflammatory disorders. He is keen on identifying a regulating network of transcription factors involved in autoimmune and inflammatory disorders so that better therapeutics can be developed.

Subject Categories

BISAC Subject Codes/Headings:
MED044000
MEDICAL / Immunology
SCI017000
SCIENCE / Life Sciences / Cytology
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology
SCI086000
SCIENCE / Life Sciences / General