This work provides detailed knowledge about the molecular features of the laminins and describes the structure-function relationships and interactions that define their biologically active domains. Many of the discoveries concerning the tissue-specific laminins and the role of different laminins are addressed. By covering topics such as gene coding for laminins, genetic diseases affecting laminins, evolutionary aspects, embryonic development, apoptosis, neurite outgrowth and cancer, this study provides a basis for understanding the role of laminins in development and disease.
Table of Contents
Biosynthesis, tissue distribution and isolation of laminins; structure of laminins and their chain assembly; laminin genes - structure, regulation and mutations in disease; laminins of epidermal structures; binding of laminins to extracellular structures; binding of laminins to extracellular matrix components; integrin-mediated cellular interactions with laminins; non-integrin laminin receptors; laminin isoferms in development; basement membrane as a differentiation and survival factor; drosophila laminin; laminins during neurite growth and nerve regeneration; interaction of tumor cells with basement membranes and laminin-1; dystroglycan - a novel laminin receptor and its involvement in the pathogenesis of muscular dystrophies.
Peter Ekblom (Uppsala University, Sweden) (Author) , R. Timpl (Max-Planck-Institut fur Biochemie, Martinsried, Germany)