Lewis Acids and Selectivity in Organic Synthesis: 1st Edition (Hardback) book cover

Lewis Acids and Selectivity in Organic Synthesis

1st Edition

By M. Santelli, J.-M. Pons

CRC Press

352 pages

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Hardback: 9780849378669
pub: 1995-11-21
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Description

Lewis acids provide inexpensive access to elaborated molecules obtained with high selectivities (regio-, stereo-, and enantioselectivity). Lewis Acids and Selectivity in Organic Synthesis is the first book to deal with these new and promising roles of Lewis acids. The book begins with general considerations on Lewis acids and a description of Lewis acid-carbonyl complexes, which are involved in most of the reactions described: ene reactions, allylsilane and allyltin addition to carbonyl compounds, addition of nucleophiles to acetals, conjugated addition of allylsilanes and allyltins to unsaturated carbonyl compounds (Sakurai reaction), and Diels-Alder reaction. Subsequent chapters examine these issue in detail, with special attention given to the way Lewis acids induce diastereo- and enantioselectivity. The extensive use of schemes (approximately 1000) ensures rapid visual uptake of the information. Lewis Acids and Selectivity in Organic Synthesis serves as a valuable source of information for all who face the challenge of selectivity in organic synthesis.

Table of Contents

Lewis Acids and Their Complexes with Lewis Bases

Lewis Acid-Promoted Ene Reaction

Lewis Acid-Promoted Allylsilanes and Allylstannanes Addition to Aldehydes and Ketones

Lewis Acid-Promoted Acetal Substitution Reactions

Sakurai Reaction: Lewis Acid-Promoted Allylsilanes and Allylstannanes 1,4-Addition to Unsaturated Ketones

Lewis Acid-Promoted Diels-Alder Reaction

Index

About the Series

Organic & Bio-organic Chemistry

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Subject Categories

BISAC Subject Codes/Headings:
SCI013040
SCIENCE / Chemistry / Organic