Lipid Oxidation in Health and Disease: 1st Edition (e-Book) book cover

Lipid Oxidation in Health and Disease

1st Edition

Edited by Corinne M. Spickett, Henry Jay Forman

CRC Press

440 pages

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pub: 2015-03-03
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Description

Oxidative modification of lipids and phospholipids-including radical damage, halogenation, and nitration-result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of

Table of Contents

An Introduction to Redox Balance and Lipid Oxidation. CHEMISTRY AND BIOCHEMISTRY OF LIPID OXIDATION. Nonenzymatic Mechanisms of Lipid Oxidation. Enzymatic Oxidation of Polyunsaturated Fatty Acids. Halogenated Lipids: Products of Peroxidase-Derived Reactive Halogenating Species Targeting Conventional Lipids. Formation of Nitrated Lipids and Their Biological Relevance. Protein Lipoxidation. Analysis of Lipid Peroxidation Products in Health and Disease. SITES OF BIOLOGICAL ACTIONS OF OXIDIZED LIPIDS. Oxidized Lipids as Damage-Associated Molecular Patterns in Inflammatory Responses. Formation and Beneficial Roles of Polyunsaturated Lipid Mediators: Lipoxins, Resolvins, Protectins, and Maresins. Pro- and Anti-Inflammatory Action of Oxidized Phospholipids. Modulation of Toll-Like Receptor Signaling by Oxidized Phospholipids. Dietary Oxidized Lipids as Regulators of Intracellular Signaling Pathways: PPAR and NF-KB. Oxidized and Nitrated Lipid Interactions with the. Keap1-Nrf2 Pathway. OXIDIZED LIPIDS IN PATHOLOGY AND DISEASE. Role of Oxidized Phospholipids in Cardiovascular Disease. Cholesterol Oxidation Products in the Initiation, Progression, and Fate of Atherosclerotic Lesions. Lipid Peroxidation and Age-Related Neurodegenerative. Disorders. Association of Oxidative Stress and Lipids with Risk Factors of Metabolic Syndrome. Oxidized Lipid Products and Carcinogenesis.

About the Editors

Corinne M. Spickett is a reader at Aston University in Birmingham, UK. She has studied the analysis of phospholipid oxidation by electrospray mass spectrometry and the biological effects of oxidized lipids. More recently, she expanded her research to include analysis of protein oxidation and formation of lipoxidation products during inflammation, and has been developing label-free, semi-targeted approaches to their identification in biological samples.

Henry Jay Forman is a distinguished professor of biochemistry and chemistry and founding faculty at the University of California, Merced. His expertise is in the areas of oxidative stress and signal transduction. His major research achievements are pioneering work in mitochondrial superoxide production, redox signaling, and mechanisms of induced resistance to oxidative stress.

Subject Categories

BISAC Subject Codes/Headings:
MED027000
MEDICAL / Endocrinology & Metabolism
SCI017000
SCIENCE / Life Sciences / Cytology
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology