Lipid Oxidation in Health and Disease: 1st Edition (Hardback) book cover

Lipid Oxidation in Health and Disease

1st Edition

Edited by Corinne M. Spickett, Henry Jay Forman

CRC Press

440 pages | 96 B/W Illus.

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pub: 2015-03-03
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Oxidative modification of lipids and phospholipids—including radical damage, halogenation, and nitration—result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes.

Covering the diverse topics that contribute to research in this important field, this book explores:

  • The mechanisms of lipid oxidation, both enzymatic and non-enzymatic
  • Antioxidant defenses and lipid oxidation
  • Lipid oxidation products and cell signaling
  • The roles of oxidized lipids in specific diseases—including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer
  • Drug targeting and the therapeutic potential of oxidized lipids

Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.


Table of Contents

An Introduction to Redox Balance and Lipid Oxidation

Corinne M. Spickett, Maria Fedorova, Ralf Hoffmann, and Henry Jay Forman


Nonenzymatic Mechanisms of Lipid Oxidation

Claus Schneider and Sean S. Davies

Enzymatic Oxidation of Polyunsaturated Fatty Acids

Sharon A. Murphy, Naser M. I. Al-Aaswad, and Anna Nicolaou

Halogenated Lipids: Products of Peroxidase-Derived Reactive Halogenating Species Targeting Conventional Lipids

David A. Ford

Formation of Nitrated Lipids and Their Biological Relevance

Andrés Trostchansky and Homero Rubbo

Protein Lipoxidation

Koji Uchida

Analysis of Lipid Peroxidation Products in Health and Disease

Michael J. Thomas


Oxidized Lipids as Damage-Associated Molecular Patterns in Inflammatory Responses

Maria Fedorova and Ralf Hoffmann

Formation and Beneficial Roles of Polyunsaturated Lipid Mediators: Lipoxins, Resolvins, Protectins, and Maresins

Nicos A. Petasis

Pro- and Anti-Inflammatory Action of Oxidized Phospholipids

Maria Philippova, Olga Oskolkova, and Valery N. Bochkov

Modulation of Toll-Like Receptor Signaling by Oxidized Phospholipids

Vlad Serbulea and Norbert Leitinger

Dietary Oxidized Lipids as Regulators of Intracellular Signaling Pathways: PPAR and NF-KB

Robert Ringseis, Denise K. Gessner, and Klaus Eder

Oxidized and Nitrated Lipid Interactions with the Keap1-Nrf2 Pathway

Emilia Kansanen and Anna-Liisa Levonen


Role of Oxidized Phospholipids in Cardiovascular Disease

Gregor Leibundgut, Adam Taleb, and Sotirios Tsimikas

Cholesterol Oxidation Products in the Initiation, Progression, and Fate of Atherosclerotic Lesions

Giuseppe Poli, Simona Gargiulo, Paola Gamba, Barbara Sottero, Fiorella Biasi, and Gabriella Leonarduzzi

Lipid Peroxidation and Age-Related Neurodegenerative Disorders

Tanea T. Reed, Zachariah P. Sellers, and D. Allan Butterfield

Association of Oxidative Stress and Lipids with Risk Factors of Metabolic Syndrome

Sampath Parthasarathy, Chandrakala Aluganti Narasimhulu, Irene Fernandez Ruiz, Kathryn Young, Vivek Krishna Pulakazhi Venu, Xueting Jiang, and Aladdin Riad

Oxidized Lipid Products and Carcinogenesis

Françoise Guéraud

About the Editors

Corinne M. Spickett is a reader at Aston University in Birmingham, UK. She has studied the analysis of phospholipid oxidation by electrospray mass spectrometry and the biological effects of oxidized lipids. More recently, she expanded her research to include analysis of protein oxidation and formation of lipoxidation products during inflammation, and has been developing label-free, semi-targeted approaches to their identification in biological samples.

Henry Jay Forman is a distinguished professor of biochemistry and chemistry and founding faculty at the University of California, Merced. His expertise is in the areas of oxidative stress and signal transduction. His major research achievements are pioneering work in mitochondrial superoxide production, redox signaling, and mechanisms of induced resistance to oxidative stress.

About the Series

Oxidative Stress and Disease

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Endocrinology & Metabolism
SCIENCE / Life Sciences / Cytology
SCIENCE / Life Sciences / Biology / Molecular Biology