1st Edition

Lipid Oxidation in Health and Disease

Edited By Corinne M. Spickett, Henry Jay Forman Copyright 2015
    440 Pages 96 B/W Illustrations
    by CRC Press

    Oxidative modification of lipids and phospholipids—including radical damage, halogenation, and nitration—result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes.

    Covering the diverse topics that contribute to research in this important field, this book explores:

    • The mechanisms of lipid oxidation, both enzymatic and non-enzymatic
    • Antioxidant defenses and lipid oxidation
    • Lipid oxidation products and cell signaling
    • The roles of oxidized lipids in specific diseases—including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer
    • Drug targeting and the therapeutic potential of oxidized lipids

    Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.


    An Introduction to Redox Balance and Lipid Oxidation
    Corinne M. Spickett, Maria Fedorova, Ralf Hoffmann, and Henry Jay Forman


    Nonenzymatic Mechanisms of Lipid Oxidation

    Claus Schneider and Sean S. Davies

    Enzymatic Oxidation of Polyunsaturated Fatty Acids
    Sharon A. Murphy, Naser M. I. Al-Aaswad, and Anna Nicolaou

    Halogenated Lipids: Products of Peroxidase-Derived Reactive Halogenating Species Targeting Conventional Lipids
    David A. Ford

    Formation of Nitrated Lipids and Their Biological Relevance
    Andrés Trostchansky and Homero Rubbo

    Protein Lipoxidation
    Koji Uchida

    Analysis of Lipid Peroxidation Products in Health and Disease
    Michael J. Thomas


    Oxidized Lipids as Damage-Associated Molecular Patterns in Inflammatory Responses

    Maria Fedorova and Ralf Hoffmann

    Formation and Beneficial Roles of Polyunsaturated Lipid Mediators: Lipoxins, Resolvins, Protectins, and Maresins
    Nicos A. Petasis

    Pro- and Anti-Inflammatory Action of Oxidized Phospholipids
    Maria Philippova, Olga Oskolkova, and Valery N. Bochkov

    Modulation of Toll-Like Receptor Signaling by Oxidized Phospholipids
    Vlad Serbulea and Norbert Leitinger

    Dietary Oxidized Lipids as Regulators of Intracellular Signaling Pathways: PPAR and NF-KB
    Robert Ringseis, Denise K. Gessner, and Klaus Eder

    Oxidized and Nitrated Lipid Interactions with the Keap1-Nrf2 Pathway
    Emilia Kansanen and Anna-Liisa Levonen


    Role of Oxidized Phospholipids in Cardiovascular Disease
    Gregor Leibundgut, Adam Taleb, and Sotirios Tsimikas

    Cholesterol Oxidation Products in the Initiation, Progression, and Fate of Atherosclerotic Lesions
    Giuseppe Poli, Simona Gargiulo, Paola Gamba, Barbara Sottero, Fiorella Biasi, and Gabriella Leonarduzzi

    Lipid Peroxidation and Age-Related Neurodegenerative Disorders
    Tanea T. Reed, Zachariah P. Sellers, and D. Allan Butterfield

    Association of Oxidative Stress and Lipids with Risk Factors of Metabolic Syndrome
    Sampath Parthasarathy, Chandrakala Aluganti Narasimhulu, Irene Fernandez Ruiz, Kathryn Young, Vivek Krishna Pulakazhi Venu, Xueting Jiang, and Aladdin Riad

    Oxidized Lipid Products and Carcinogenesis
    Françoise Guéraud


    Corinne M. Spickett is a reader at Aston University in Birmingham, UK. She has studied the analysis of phospholipid oxidation by electrospray mass spectrometry and the biological effects of oxidized lipids. More recently, she expanded her research to include analysis of protein oxidation and formation of lipoxidation products during inflammation, and has been developing label-free, semi-targeted approaches to their identification in biological samples.

    Henry Jay Forman is a distinguished professor of biochemistry and chemistry and founding faculty at the University of California, Merced. His expertise is in the areas of oxidative stress and signal transduction. His major research achievements are pioneering work in mitochondrial superoxide production, redox signaling, and mechanisms of induced resistance to oxidative stress.