Liposomes have been widely explored in the drug delivery realm over the past decades. Many of the properties that made them well suited for drug delivery applications, such as the internal space to encapsulate a large payload of molecules and the inherent protection from exterior stresses, have also been exploited in various analytical techniques. Liposomes in Analytical Methodologies provides an extensive coverage of their utility, ranging from historic developments to actively researched techniques written by expert investigators. The introductory chapter serves as a primer on the fundamentals of liposomes for analytical purposes and provides an overview of various applications, while subsequent chapters provide in-depth coverage of selected areas. With techniques ranging from liposome PCR to electrophoretic separations, readers will gain an appreciation for the versatility that liposomes can add to the analytical toolbox.
Table of Contents
The analytical utility of liposomes: from the past to the present; K. Edwards
Applications of liposomes in lateral flow assays; H. W. Wen et al.
Application of liposomes in proteome microarrays for the study of lipid-protein interactions; C. S. Chen et al.
Functional polydiacetylene liposomes as self-signaling and signal amplifying bio-and chemical sensor and sensor array; J. Kim et al.
Taking advantage of liposomes in microfluidic systems; A. J. Baeumner et al.
Redox liposomes in the development of electrochemical sensors; J. A. Ho, et al.
Coupling liposome-encapsulated nucleic acids with the polymerase chain reaction: a generic assay platform for high-sensitivity analyte detection; J. Mason et al.
Magnetic liposomes in imaging and analysis; K. Edwards
Liposome-based methodologies to assess pharmacokinetic parameters of drugs; M. Langner et al. Liposomes in capillary electromigration techniques; S. Wiedmer
Fluorescent dye-encapsulating liposomes for cellular visualization; A. Csiszár et al.
Katie A. Edwards is a scientist and lecturer at Cornell University. She earned her MS and PhD in toxicology from Cornell University and BS in chemistry from Clarkson University. Her work has primarily focused on the advancement of liposomes as analytical tools, utilizing her background in organic synthesis, lipid formulation, and novel biorecognition strategies to develop high-throughput laboratory-based methods and point-of-care diagnostics for analytes of environmental, national security, and clinical interest.
"In the past 40 years since their discovery, liposomes have found widespread applications in biomimetic membrane research, drug delivery, and cosmetic encapsulation and in the topic of this book, as analytical reagents. This well-illustrated book has been written by recognized experts in the field of liposomal analysis and includes chapters on the most important applications and their relevant technologies. Liposomes in Analytical Methodologies is an outstanding review of the state of the art of using liposomes for analytical purposes."
—Prof. Richard A. Durst, Cornell University, USA