Liquid Chromatography-Mass Spectrometry: 3rd Edition (Hardback) book cover

Liquid Chromatography-Mass Spectrometry

3rd Edition

By Wilfried M.A. Niessen

CRC Press

632 pages | 139 B/W Illus.

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pub: 2006-08-09
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A constructive evaluation of the most significant developments in liquid chromatography–mass spectrometry (LC–MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, Liquid Chromatography–Mass Spectrometry, Third Edition offers a well-rounded coverage of the latest technological developments and applications.

As the technology itself has matured into a reliable analytical method over the last 15 years, the most exciting developments occur in LC–MS augments research into new applications. This edition places a stronger emphasis than previous editions on the impact of LC–MS methods, dedicating two-thirds of the text to small-molecule and biomolecular applications such as proteomics, pharmaceutical drug discovery and development, biochemistry, clinical analysis, environmental studies, and natural products research. Supported by the most relevant literature available, each chapter examines how the strategies, technologies, and recent advances—from sample pretreatment to data processing—in LC–MS helped to shape these disciplines.

Featuring new chapters and extensive revisions throughout the book, Liquid Chromatography–Mass Spectrometry, Third Edition continues to provide scientists with a definitive guide and reference to the most important principles, strategies, and experimental precedents for applying LC–MS to their research.


"This book offers a well-rounded coverage of the latest technological developments and applications … "

—Anticancer Research, October 2008

“… this book covers a variety of topics that are of interest to practitioners of LC-MS. The 22 chapters cover multiple topics and include practical tips as well as a useful list of references for the reader who wants to learn more about the particular topic. This book can be used as a reference book by both scientists with years of LC-MS experience as well as those scientists who are just beginning to utilize this excellent analytical tool.”

— Walter A. Korfmacher, Exploratory Drug Metabolism, Schering-Plough Research Institute, New Jersey, in American Society for Mass Spectrometry, 2007

”…Features new chapters and extensive revisions. …Discusses how the technique works and how to interpret results. …Describes the impact of [LC-MS] on small-molecule and biomolecular applications…”

— Biophotonics International, August 2006

Table of Contents


Liquid Chromatography and Sample Pretreatment

Mass Spectrometry


Strategies in LC–MS Interfacing

History of LC–MS Interfaces

Interfaces for Atmospheric-Pressure Ionization

Atmospheric-Pressure Ionization


LC–MS Analysis of Pesticides

Environmental Applications of LC–MS

LC–MS in Drug Discovery and Development

LC–MS in Drug Metabolism

Quantitative Bioanalysis Using LC–MS

Clinical Applications of LC–MS

LC–MS Analysis of Steroids

LC–MS in Food Safety Analysis

LC–MS Analysis of Plant Phenols


LC–MS analysis of Proteins

LC–MS analysis of Peptides / Enabling Technology

LC–MS in Proteomics

LC–MS for Identification of Post-Translational Modifications

LC–MS Analysis of Oligosaccharides

LC–MS Analysis of Lipids and Phospholipids

LC–MS Analysis of Nucleic Acids INDEX

About the Series

Chromatographic Science Series

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
SCIENCE / Chemistry / General
SCIENCE / Chemistry / Industrial & Technical
SCIENCE / Research & Methodology