The Zika virus has challenged conventional ideas of mosquito-borne diseases, tested the resilience of global health systems and embedded itself within local sociocultural worlds, with major implications for environmental, sexual, reproductive and paediatric health, science and policy. This book locates the 2016 Zika epidemic in Latin America and the Caribbean within its broader biosocial and historical context. The chapters contain a diverse set of case studies from scholars and health practitioners working across the region including Brazil, Venezuela, Ecuador, Mexico, Colombia, the United States, and Haiti. The book explores how mosquito-borne disease epidemics (not only Zika but also chikungunya, dengue and malaria) intersect with social change and health governance. It critically reflects on the ways in which situated knowledge and social science approaches can contribute to more effective global health policy and practice for mosquito-borne disease threats in a changing world.