Lymphocyte Homing to the Skin: Immunology, Immunopathology, and Therapeutic Perspectives, 1st Edition (Hardback) book cover

Lymphocyte Homing to the Skin

Immunology, Immunopathology, and Therapeutic Perspectives, 1st Edition

Edited by Wolf-Henning Boehncke

CRC Press

224 pages | 31 B/W Illus.

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Hardback: 9780849325281
pub: 2004-12-28
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Description

Over the last decade, enormous progress in the understanding of T-cell homing has made it possible to identify the multitude of molecules involved, such as cytokines, chemokines, and adhesion molecules, and to unravel their complex interactions resulting in controlled, non-random T-cell recirculation. These insights are now being explored therapeutically, with several compounds close to approval.

Highlighting key findings in the field, Lymphocyte Homing to the Skin: Immunology, Immunopathology, and Therapeutic Perspectives brings insight to the physiology and pathophysiology of T-cell homing as a process, as well as to the manipulation of this process for therapeutic benefit. The book begins with a review of the role of T-lymphocytes in skin biology, followed by coverage of the process of lymphocyte recruitment, and lymphocyte homing to the skin. Subsequent chapters describe in vitro techniques to investigate lymphocyte extravasation, in vivo methods to study lymphocyte homing to the skin, and cutaneous T-lymphocytic infiltrates in skin pathology. The text concludes with discussions on translating cutaneous T-cell recruitment to patients.

Providing a timely update on T-cell homing, this book clarifies our understanding of this complex process and offers guidance on potential therapies. It fulfills the needs of those involved in skin biology, skin toxicology, and dermatology, and proposes new directions for innovative research.

Table of Contents

THE ROLE OF T-LYMPHOCYTES IN SKIN BIOLOGY, Michael P. Schön

A Brief View on T-Cells in the Immune System

Cutaneous Recruitment - The Bare Essentials

Tethering and Rolling - The First Steps of Leukocyte Extravazation

Lymphocyte Extravazation - Teamwork of Chemokines and Adhesion Molecules

Epidermal Localization - The Endpoint of a Long Journey

Psoriasis a Model Disease For Studying Cutaneous T-Cell Recruitment

THE PROCESS OF LYMPHOCYTE RECRUITMENT, John M. Hwang and Paul Kubes

The Multi-Step Paradigm

Tethering And Rolling

Selectins And Their Receptors

Selectin Signaling

Firm Adhesion

Chemokines and Chemokine Receptors

Integrins and Their Receptors

Affinity and Avidity Modulation

Transendothelial Migration

Cell Spreading And Locomotion

Cell Junctions

Chemotaxis

LYMPHOCYTE HOMING TO THE SKIN, Takako Hirata, Barbara C. Furie, and Bruce Furie

Adhesion Molecules and the Skin-Specific Migration of Lymphocytes

Rolling Receptors on Lymphocytes and Endothelium

Role of Glycosyltransferases and Sulfotransferases in Selectin Lignad Formation

Adhesion Molecules Mediating Firm Adhesion of Lymphocytes

Adhesion Molecules in Transmigration of Lymphocytes

Dermal Localization of Lymphocytes

Epidermal Localization of Lymphocytes

Chemokines and Skin-Specific Migration of Lymphocytes

Chemokines in Lymphocyte Trafficking

Chemokine Smediating Transition From Rolling to Arrest

Chemokines in Transmigration of Lymphocytes

Chemokines and Lymphocyte Migration Within the Skin

IN VITRO TECHNIQUES TO INVESTIGATE LYMPHOCYTE EXTRAVAZATION, Judith W. Calderwood and Heinfried H. Radeke

Chemokines Activate Adhesion of Lymphocytes

Binding to Cell-Free Matrix and Adhesion Molecules - Static Adhesion Assays

Chemokines Regulate Cell-Cell Interaction - Binding of Immune Cells to EC and Other Tissue Cells Including the Stamper-Woodruff Assay

Determination of Chemotaxis and Chemokinesis

Single Cell Tracking

Wound Healing Assay

Variations of a Classical Theme: From Boyden to High-Thru Put Chemotaxis Assays

Transendothelial Migration (Tem) Under Static Conditions and Migration to Multiple Chemokine Gradients Imprinted in Inflamed Matrices

Tethering, Adhesion and Migration Under Flow Conditions

Selectin-Dependent Rolling

Integrins, Firm Adhesion and Spreading Under Flow Conditions

IN VIVO METHODS TO STUDY LYMPHOCYTE HOMING TO THE SKIN, Ralf J. Ludwig, Wolf-Henning Boehncke

Intravital Microscopy

Rationale for the Use of Intravital Microscopy

Extravazation of Endogenous Lymphocytes

Extravazation of Injected Lymphocytes

Microscope and Recording Equipment

Data Evaluation

Animal Models

Rationale For the Use of Animal Models

Cutaneous Inflammation in Wild-Type Animals

Cutaneous Inflammation in Genetically Modified Mice

Cutaneous Inflammation in Xenogeneic Skin Transplantation Models

Drug Discovery Using Animal Models

CUTANEOUS T-LYMPHOCYTIC INFILTRATES IN SKIN PATHOLOGY, Richard Groves

Inflammatory Skin Diseases

Eczema

Psoriasis

Lichen Planus

Cutaneous Organ-Specific Autoimmune Disease: Alopecia Areata and Vitiligo

Cutaneous Malignancies

Non-Melanoma Skin Cancer

Melanoma

Cutaneous T-Cell Lymphoma

Therapeutic Perspectives

FROM BENCH TO BEDSIDE: BRINGING UNDERSTANDING OF CUTANEOUS T-CELL RECRUITMENT TO PATIENTS, Arndt J. Schottelius, Khusru Asadullah, and Thomas M. Zollner

Emerging Targets for Interfering with T-Cell Trafficking

Targeting Lymphocyte Rolling Along the Blood Vessel Wall

Blockade of Chemokine - Chemokine Receptor Interaction

Blockade of Firm Adhesion of Lymphocytes to the Blood Vessel Wall

Challenges of Targeting Lymphocyte Skin Homing

Subject Categories

BISAC Subject Codes/Headings:
MED017000
MEDICAL / Dermatology
MED044000
MEDICAL / Immunology
MED071000
MEDICAL / Pharmacology