Magnesium Alloys as Degradable Biomaterials: 1st Edition (Hardback) book cover

Magnesium Alloys as Degradable Biomaterials

1st Edition

By Yufeng Zheng

CRC Press

578 pages | 253 B/W Illus.

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pub: 2015-10-09
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Description

Magnesium Alloys as Degradable Biomaterials provides a comprehensive review of the biomedical applications of biodegradable magnesium and its alloys. Magnesium has seen increasing use in orthopedic and cardiovascular applications over the last decade, particularly for coronary stents and bone implants.

The book discusses the basic concepts of biodegradation mechanisms as well as strategies to control biodegradation mode and rate, microstructure, mechanical properties, corrosion resistance to body fluid, and in vitro and in vivo biocompatibility.

The recently developed representative magnesium alloy systems—such as Mg-Ca, Mg-Zn, Mg-Sr, Mg-Ag, Mg-Li, and Mg-RE—are reviewed and their special properties illustrated. Also discussed are the biodegradable magnesium alloys/aqueous solution interface theoretical model and potential application prototypes, such as for cardiology and orthopedic surgery products.

Challenges of transitioning biodegradable magnesium alloys from raw materials to semi-products to final medical devices are covered along with main findings of worldwide experimental studies. An ideal reference book for researchers in the area of biodegradable metals, it presents the state of the art of magnesium alloys designed for biomedical applications.

Table of Contents

Introduction

Property and Function of Element Mg

History of Mg and Its Alloys for Biomedical Applications

Design of Mg and Its Alloys for Biomedical Applications

Comparison with Other Biomaterials

General Analytical Methods for Biodegradable Mg and Its Alloys

Biodegradation Mechanism and Influencing Factors of Mg and Its Alloys

Biodegradation Mechanism of Pure Mg in the Physiological Environment

Influence of Alloying Elements and Impurities on the Biodegradation of Mg and Its Alloys

Degradation Mode and Rate of Mg and Its Alloys in the Physiological Environment

Influence of Environmental Variables on the Biodegradation of Mg and its Alloys

Biological Effects of Degradation Products

Concluding Remarks

Novel Structure Design for Biodegradable Mg and Its Alloys

Introduction

Porous Structure

Composites

Ultrafine-Grained Structure

Glassy Structure

Concluding Remarks

Surface Modification Techniques for Biodegradable Mg and Its Alloys

Introduction

Mechanical Surface Treatment

Physical Surface Treatment

Chemical Surface Treatment

Concluding Remarks

Mg with High Purity for Biomedical Application

Introduction

Development of Pure Mg as Degradable Metallic Biomaterial

New Advances in Property Improvements on Pure Mg for Medical Purposes

Concluding Remarks

Mg-Ca–Based Alloy Systems for Biomedical Applications

Introduction

Development of Mg-Ca Binary Alloys as Degradable Metallic Biomaterials

Development of Mg–Ca–X Ternary Alloys as Degradable Metallic Biomaterials

Development of Mg-Ca Quaternary and Multielementary Alloys as Degradable Metallic Biomaterials

Concluding Remarks

Mg-Zn–Based Alloy Systems for Biomedical Application

Introduction

Development of Mg-Zn Binary Alloys as Degradable Metallic Biomaterials

Development of Mg-Zn Ternary Alloys as Degradable Metallic Biomaterials

Development of Mg-Zn Quaternary Alloys as Degradable Metallic Biomaterials

Concluding Remarks

Mg-Sr–Based Alloy Systems for Biomedical Applications

Introduction

Development of Mg-Sr Binary Alloys as Degradable Metallic Biomaterials

Development of Mg-Sr Ternary Alloys as Degradable Metallic Biomaterials

Development of Mg-Sr Quaternary Alloys as Degradable Metallic Biomaterials

Concluding Remarks

Mg-Ag–Based Alloy System for Biomedical Applications

Introduction

Development of Mg-Ag Binary Alloys as Degradable Metallic Biomaterials

Development of Mg-Ag–Based Alloys as Degradable Metallic Biomaterials

Possible Methods of Property Improvement for Mg-Ag–Based Alloy Systems

Concluding Remarks

Mg-Li–Based Alloy Systems for Biomedical Applications

Introduction

Development of Mg-Li Binary Alloys as Degradable Metallic Biomaterials

Development of Mg-Li-X Ternary Alloys as Degradable Metallic Biomaterials

Development of Mg-Li Quaternary and Multielementary Alloys as Degradable Metallic Biomaterials

New Advances in Property Improvements for Mg-Li–Based Alloy Systems

Concluding Remarks

Mg-RE–Based Alloy Systems for Biomedical Application

General Introduction

Mg-Y–Based Alloys for Biomedical Applications

Mg-Nd–Based Alloys for Biomedical Applications

Mg-Dy–Based Alloys for Biomedical Applications

Other Rare Earth Metals in Mg Alloys

Conclusions on Mg-RE–Based Biomedical Mg Alloys

Fabrication and Processing of Biodegradable Mg and Its Alloys: From Raw Materials to Final Medical Devices

Introduction

Fabrication of Biodegradable Mg Alloy Raw Materials

Forming of Biodegradable Mg Alloy Semiproducts

Machining and Cutting of Biodegradable Mg Alloys

Finishing of Biodegradable Mg Alloys

Joining of Biodegradable Mg Alloys

Sterilization of Biodegradable Mg Alloys

Concluding Remarks

Design of Biodegradable Mg Alloy Implants with Finite Element Analysis

Introduction

FEA in the Design of Bone Implants

FEA in the Design of Stents

Concluding Remarks: Future

In Vivo Testing of Biodegradable Mg Alloy Implants

In Vivo Testing of Biodegradable Mg Alloy Implants within Bone

In Vivo Testing of Biodegradable Mg Alloy Implants within Blood Vessels

In Vivo Testing of Biodegradable Mg Alloy Implants within the Nonvascular Lumen

Concluding Remarks

About the Author

Yufeng Zheng, PhD,is a professor at Peking University in Beijing, China and was an associate full professor at the Harbin Institute of Technology in China, where he received his PhD in materials science. His areas of special interest include the development of various new biomedical metallic materials. He served as a member of the editorial board of various journals including the Journal of Biomedical Materials Research-Part B: Applied Biomaterials, the Journal of Biomaterials and Tissue Engineering, Materials Letters, Intermetallics, the Journal of Materials Science & Technology, Frontiers of Materials Science, Acta Metallurgica Sinica, Progress in Natural Science: Materials International, and the Journal of Orthopaedic Translation. Dr. Zheng has authored or co-authored more than 330 peer-reviewed articles.

Subject Categories

BISAC Subject Codes/Headings:
TEC021000
TECHNOLOGY & ENGINEERING / Material Science
TEC023000
TECHNOLOGY & ENGINEERING / Metallurgy
TEC059000
TECHNOLOGY & ENGINEERING / Biomedical