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Mammalian Heme Peroxidases
Diverse Roles in Health and Disease



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ISBN 9780367820367
September 30, 2021 Forthcoming by CRC Press
376 Pages 61 Color & 17 B/W Illustrations

 
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Book Description

Peroxidasins are a family of heme peroxidases that play a novel role in tissue biogenesis and matrix assembly. Mammalian heme peroxidase enzymes are critical for immune responses and disease prevention. Although highly beneficial, overproduction drives the development of pathologies, including cardiovascular, neurodegenerative, respiratory, kidney and inflammatory bowel diseases by triggering the initiation of stress-related pathways leading to cell damage and dysfunction. This book highlights the roles of mammalian heme peroxidases, as well as their involvement in immunity and disease, and potential therapeutic approaches to modulate and prevent damaging reactions.

Table of Contents

SECTION 1: INTRODUCTION TO MAMMALIAN HEME PEROXIDASES

Chapter 1: Evolution, structure and biochemistry of human peroxidases

Paul G. Furtmüller, Marcel Zámocký, Stefan Hofbauer, Christian Obinger*

Chapter 2: Biosynthesis of mammalian heme proteins, peroxidases and NADPH oxidases

William M. Nauseef*

Chapter 3: Peroxidasin structure and function

Gábor Sirokmány, Hajnal A. Kovács, Miklós Geiszt*

SECTION 2: REACTIVITY OF PEROXIDASE OXIDANTS

Chapter 4: Reactivity of peroxidase-derived oxidants with proteins, glycoproteins and proteoglycans

Michael J. Davies*

Chapter 5: Reactivity of hypochlorous acid (HOCl) with nucleic acids, RNA and DNA.

Clare L. Hawkins*

Chapter 6: Reactivity of peroxidase oxidants with lipids: The generation of biologically important modified lipids

Daniel P. Pike and David A. Ford*

Chapter 7: Roles of myeloperoxidase in the oxidation of apolipoproteins: Interest of monitoring MPO oxidation of apolipoproteins A-1 and B-100 to improve the estimation of lipoprotein quality in cardiovascular diseases

Catherine Coremans, Karim Zouaoui Boudjeltia, Pierre Van Antwerpen and Cédric Delporte*

Chapter 8: Global profiling of cell responses to (pseudo)hypohalous acids

Joshua Chandler*

SECTION 3: PEROXIDASES IN INNATE IMMUNITY

Chapter 9: MPO and immune cell recruitment and activation

Anne Klinke and Martin Mollenhauer*

Chapter 10: Bactericidal activity of the oxidants derived from mammalian heme peroxidases

Heather L. Shearer, Nina Dickerhof and Mark B. Hampton*

Chapter 11: Priming the innate immune system to combat respiratory disease

Brian Day*

SECTION 4: PEROXIDASES IN PATHOLOGY

Chapter 12: Imaging the reactivity of MPO in vivo

Cuihua Wang, Negin Jalali Motlagh, Enrico G. Kuellenberg, and John W. Chen*

Chapter 13: Role of MPO in endothelial dysfunction and cell signaling in atherosclerosis

Benjamin Rayner*

Chapter 14: MPO in ischemic heart disease

Dennis Mehrkens, Simon Geißen, Stephan Baldus, and Volker Rudolph*

Chapter 15: Role of MPO in neurodegenerative disease

Wanda F. Reynolds* and Richard A. Maki

Chapter 16: The pathogenesis and consequences of MPO-dependent ANCA and glomerulonephritis 

Meghan E. Free*, Dominic J. Ciavatta, J. Charles Jennette and Ronald J. Falk

Chapter 17: Role of peroxidasins in disease

Gautam Bhave*

SECTION 5: PREVENTION OF MPO INDUCED DAMAGE

Chapter 18: Structure, function, and mechanistic insights into a novel family

of myeloperoxidase inhibitory proteins expressed by Staphylococci

Molly Allison, Nitin Mishra and Brian V. Geisbrecht*

...
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Editor(s)

Biography

Clare Hawkins is a Professor in the Department of Biomedical Sciences, University of Copenhagen. She appointed in March 2017 after nearly 20 years in Sydney at the Heart Research Institute, where she held the position of Scientific Director and the Inflammation Group Leader. Clare is a former Australian Research Council Future Fellow, and Principal Research Fellow within Sydney Medical School, University of Sydney. She completed her PhD in Chemistry at the University of York (UK) before making the move to Sydney where she eventually became Head of the Inflammation Group at the Heart Research Institute. Her research is focused on understanding how chemical oxidants modulate cellular function under inflammatory conditions, and the role of these reactions in the pathogenesis of inflammatory diseases, including atherosclerosis. Prof Hawkins has been awarded prestigious Career Development Awards including a R. Douglas Wright Biomedical Fellowship from the National Health and Medical Research Council (NHMRC) of Australia in 2003, a Career Development Fellowship from the National Heart Foundation of Australia (NHF), and an Australian Research Council (ARC) Future Fellowship, together with project grants from both European and Australian funding agencies. She has authored several book chapters and about 100 peer-reviewed journal articles in high-quality, journals, attracting more than 5000 citations.

William M. Nauseek is a professor in the Department of Microbiology at the University of Iowa. He also serves as the Director of the Inflammation Program, also at the University of Iowa. He received his MD from the SUNY Upstate Medical Center, Syracuse, New York. He is Board Certified by the American Board of Internal Medicine in Infectious Diseases. He is the author or co-author of over 180 peer reviewed papers, has co-authored 2 books, and co-authored dozens of book chapters. His research program over the past ~ four decades has focused on elucidating the cell and molecular biology of human neutrophils within the context of innate host defense against infection.