Manual of Hypertension of the European Society of Hypertension: 2nd Edition (Hardback) book cover

Manual of Hypertension of the European Society of Hypertension

2nd Edition

Edited by Giuseppe Mancia, Guido Grassi

CRC Press

635 pages | 199 Color Illus.

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pub: 2014-06-22
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Despite recent advances in healthcare, hypertension is a leading cause of death and remains a disease burden worldwide. Now in its second edition, the Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to this condition. Updating all material, this new edition also delves into a number of areas that have received heightened interest in recent years or have become a matter of debate due to the controversial interpretation of the available data.

Topics include:

  • Background, history, and epidemiology of hypertension
  • Risk factors such as pulse pressure, high heart rate, obesity, diabetes, and stress
  • Etiological and pathophysiological aspects, including hemodynamics and genetics
  • Hypertension-based damage to body organs and systems
  • Blood pressure measurements and other diagnostic procedures
  • Pharmacological, nonpharmacological, and medical treatments
  • Hypertension in special populations, including diabetic patients, children, during pregnancy, and post-transplant
  • Cost-benefit aspects of hypertension treatment and running a hypertension center

Each topic is addressed in a format that will be of interest not only to investigators and students who conductstudies on hypertension and its cardiovascular andrenal complications, but also to clinicians needing in-depth information on diagnostic and therapeutic aspects. The book is an essential guide to all facets of this debilitating condition that remains a threat to public health.


"This is a significant and relevant addition to the hypertension literature … It serves well as a useful reference for practicing clinicians and trainees with an interest in hypertension as well as for investigators in the field."

—Joaquin Crespo, MD, Ochsner Clinic Foundation for Doody's Review Service

Table of Contents

Background, History and Epidemiology

Epidemiology of Hypertension; Renata Cífková

The Total Cardiovascular Risk; Claudio Borghi, Arrigo Francesco Giuseppe Cicero, and Ettore Ambrosioni

Associated Risk Factors

Classical and New Risk Factors; Manolis S. Kallistratos and Athanasios J. Manolis

Pulse Pressure as a Cardiovascular Risk Factor; Athanase Benetos

Clinical Significance of High Heart Rate in Hypertension; Paolo Palatini and Guido Grassi

Obesity and Obstructive Sleep Apnea; Marzena Chrostowska, Anna Szyndler, Jacek Wolf, and Krzysztof Narkiewicz

Diabetes Mellitus; Peter M. Nilsson

Stress, Psychosocial, and Other Risk Factors in the Hypertensive Patient; Philippe Van De Borne

Blood Pressure Variability: Methodological Aspects, Pathophysiological and Clinical Implications; Gianfranco Parati, Juan Eugenio Ochoa, and Grzegorz Bilo

Antihypertensive Treatment Strategies; Giuseppe Mancia

Ethiological and Pathophysiological Aspects

Hemodynamics of Hypertension; Per Omvik and Per Lund-Johansen

Genetic Basis of Blood Pressure and Hypertension; Sandosh Padmanabhan, Mark Caulfield, and Anna F. Dominiczak

Structural Cardiovascular Changes in Hypertension; Harry A.J. Struijker-Boudier

Impaired Autonomic Cardiovascular Control in Hypertension; Guido Grassi, Gianmaria Brambilla, and Gino Seravalle

The Renin–Angiotensin–Aldosterone System; Ulrike M. Steckelings and Thomas Unger

Etiological and Pathophysiological Aspects of Hypertension: Other Humoral–Endocrine Factors; Michel Burnier

Target Organ Damage: Measurements/Clinical Importance

Cardiac Damage and Progression to Heart Failure; E. Agabiti Rosei, M.L Muiesan, and R.E. Schmieder

Brain Damage; Cristina Sierra and Antonio Coca

Large Artery Damage: Measurement and Clinical Importance; Stéphane Laurent, and Michel E Safar

Small Artery Structure and Function in Hypertension; Anthony M. Heagerty, Sarah B. Withers, Ashley S. Izzard,

Adam S. Greenstein, and Reza Aghamohammadzadeh

Endothelial Damage: Measurement and Clinical Importance; Lorenzo Ghiadoni, Agostino Virdis, and Stefano Taddei

Renal Damage and Hypertension: Mechanisms of Renal End-Organ Damage; Hermann Haller

Retinal Changes in Hypertension; Martin Ritt, Enrico Agabiti-Rosei, and Roland E Schmieder

BP Measurements and Other Diagnostic Procedures

BP Measurements and Other Diagnostic Procedures; Jean-Philippe Baguet, Jean-Michel Mallion, and Denis L. Clement

Blood Pressure Response to Acute Physical and Mental Stress; Robert Fagard and Guido Grassi

Central Blood Pressure; Cristina Giannattasio and Stéphane Laurent

The Diagnostic Approach in Uncomplicated and Complicated Hypertension; Athanasios J. Manolis and Costas Tsioufis

Therapeutic Aspects

Blood Pressure Targets of Antihypertensive Treatment; Giuseppe Mancia and Guido Grassi

Interventional Trials in Hypertension: What Have We Learned and What Remains to be Learned? Alberto Zanchetti

The Nephroprotective Effect of Antihypertensive Treatment; Luis M. Ruilope and Julian Segura

Nonpharmacological Interventions; Stefan Engeli and Jens Jordan

Medical Treatment of Hypertension: Monotherapy and Combination Therapy; M. Burnier, G. Wuerzner and B. Waeber

Emerging Antihypertensive Drugs; Massimo Volpe and Giuliano Tocci

The Polypill; Marie Briet and Michel Azizi

Invasive Procedures; Roland E. Schmieder

Special Conditions

Clinical Management of Patients Presenting with Hypertension and Peripheral Artery Disease; Denis L. Clement

Resistant and Malignant Hypertension; Josep Redon, Fernando Martinez, and Gernot Pichtler

Hypertensive Emergencies and Urgencies; Cesare Cuspidi and Achille C. Pessina

Secondary Hypertension: Diagnosis and Treatment; Peter W De Leeuw

Hypertension in Diabetes Mellitus; Peter M. Nilsson

Hypertension in Children and Adolescents; Empar Lurbe

Hypertension in Pregnancy; Renata Cífková

Posttransplant Hypertension; Martin Hausberg and Karl Heinz Rahn

Hypertension in Patients with Renal Parenchymal Disease, Chronic Renal Failure, and Chronic Dialysis; Jose L. Rodicio and Jose A. García-Donaire

The Metabolic Syndrome in Hypertension; Josep Redon, Fernando Martinez and Maria Jose Fabia

White-Coat and Masked Hypertension; Robert Fagard

Secondary Prevention of Stroke; Miguel Camafort, Monica Doménech and Antonio Coca

Hypertension and Atrial Fibrillation: Modern Epidemiologic, Pathophysiologic, and Therapeutic Aspects; Athanasios J. Manolis, L.E. Poulimenos, J Kostis

Management of Perioperative Hypertension; Paul E. Marik

Economic and Organizational Issues

Pharmacoeconomic and Cost–Benefit Aspects; Ettore Ambrosioni and Claudio Borghi

How to Organize and Run a Hypertension Center; Csaba Farsang and Margus Viigimaa

Current Problems

Blood Pressure Control in Europe; Bernard Waeber, François Feihl and Giuseppe Mancia

Hypertension in the Very Elderly; Nigel S. Beckett

Hypertension in Acute Stroke; Terence J. Quinn, John A. Goodfellow and John L. Reid

Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drugs; Csaba Farsang

Compliance to Treatment in Hypertension; Serap Erdine and Margus Viigimaa

Antihypertensive Treatment in Patients with Heart Failure; Nisha B. Mistry, Sverre E. Kjeldsen, and Arne S. Westheim

Residual Risk and Resistance to the Benefits of Antihypertensive Treatment; Alberto Zanchetti


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Cardiology