1st Edition

Mechanisms and Concepts in Toxicology

ISBN 9780748404131
Published February 15, 1996 by CRC Press
254 Pages

USD $69.95

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Book Description

Illustrating concepts and types of toxicity from a mechanistic point of view, this book focuses on research procedures in toxicology. The book uses examples of chemical intoxicants to illustrate mechanisms in each stage of toxicity.

Table of Contents

Scope of Toxicology

Stages in the Induction of Toxicity

Kinetics and End-points

Acute and Chronic Intoxication

Delivery of Intoxicant: Decrease in Delivery to the Target

Delivery of Intoxicant: Bioactivation and Increase in Delivery to the Target

Initiating Reactions with Targets

Biological Consequences of Initiating Reactions with Targets

Exposure, Dose and Chemical Structure, Response and Activity, and Thresholds

Selective Toxicity, Animal Experimentation and In Vitro Methods



Environmental and Ecotoxicology

Reflections, Research and Risk

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Aldridge, W. Norman