Mechanisms of Differentiation : Volume 2 Modulation of Differentiation by Exogenous Agents book cover
1st Edition

Mechanisms of Differentiation
Volume 2 Modulation of Differentiation by Exogenous Agents

Edited By

Paul B. Fisher

ISBN 9780367260590
Published January 12, 2022 by CRC Press
205 Pages

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Book Description

First published in 1990: Mechanisms of Differentiation, Volumes 1 and 2, is comprised of review chapters addressing various topics of current interest in this important area of research. Topics discussed include genes controlling differentiation, changes in gene expression during differentiation, induction of differentiation, induction of differentiation as a mode of action of chemotherapeutic agents, and the effect of cell shape, growth factors and differentiation modulating agents on the differentiated cell phenotype.

Table of Contents

1. Modulation of Differentiation: Potential Mechanism by Which Interferons Induce Antitumor Activity

M.A. Ahmed et al.

2. Regulation of Tumor Antigen Expression by Recombinant Interferons

F. Guadagni et al.

3. Induction of Terminal Differentiation of Human Leukemic Cells by Chemotherapeutic and Cytotoxic Drugs

K. Yamamoto and H.P. Koeffler

4. Induced Differentiation of Transformed Cells with Polar/Apolar Compounds and the Reversibility of the Transformed Phenotype

R.A. Rifkind, R. Breslow, and P.A. Marks


P.A. Jones

6. Induction of Differentiation in Fibroblast Cells by Irradiation and Chemical Carcinogens

D.L. Guernsey

7. The Early Reactions and Factors Involved in In Vitro Erythroid Differentiation of Mouse Erythroleukemia (MEL) Cells

M. Oishi and T. Watanabe

8. Regulation of Cell Contacts, Cell Configuration and Cytoskeletal Gene Expression in Differentiating Systems

Ben-Ze’ev et al

9. Macrophage and Granulocyte Macrophage-Colony Stimulating Factor Effects on Human Monocyte Differentiation

R. A. Mufson

10. Regulation of Phenotype by Transforming Growth Factor-b: Role of the Extracellular Matrix

R.A. Ignotz and J. Massague

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Dr Paul B. Fisher, Ph.D. is Director of Neuro-Oncology Research and a Chernow Research Scientist in the Department of Neurosurgery, Pathology and Urology, Cancer Center/Institute of Cancer Rsearch, Columbia University, College of Physicians and Surgeons, New York, New York.