Mechanisms of Protease Action: 1st Edition (Hardback) book cover

Mechanisms of Protease Action

1st Edition

By Laszlo Polgar

CRC Press

232 pages

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Hardback: 9780849369018
pub: 1989-01-31

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A uniform treatment of the four protease groups and a discussion of the differences and similarities in their action is presented in this important new publication. Serine, cysteine, aspartate, and zinc proteases are systematically discussed by nomenclature, evolution, specificity and their regulatory role. The chemistry of the peptide bond, including the catalysis of ester and peptide hydrolyses, is explained.

For each protease group the emphasis is placed on the structure and function. Kinetics, enzyme modifications, isotope effects, subzero temperature investigations, nuclear magnetic resonance measurements, X-ray diffraction data, binding of transition-state analogs, zymogen activation, and site-specific mutagenesis are combined to rationalize the action of proteases. Both natural and synthetic inhibitors are considered because of their importance in mechanistic studies and drug design.

Table of Contents

The Chemistry of the Peptide Bond. General Aspects of Proteases. Serine Proteases. Cysteine Proteases. Aspartic Proteases. Metalloproteases. Index.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry