Mechanobiology of Living Systems
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This text brings together mechanobiology theory, approaches, and applications in a format appropriate for readers with some mathematical and biological exposure. It begins by explaining fundamental mechanobiological principles in a sequential "ground up" approach that includes key terminology. Next, it identifies the in vivo mechanical environment of biological systems—highlighting areas of important research. Maintaining a focus on mechanobiology fundamentals, it includes example questions drawn from a variety of organ systems, lower organisms, and plants. This comprehensive resource includes example problems drawn from theory and applications in each chapter, as well as sections on experimental methods.
Table of Contents
Mechanics of Adhesion and Signaling
Strain Based Mechanotransduction
Hemodynamics Based Signaling
Mechanobiology of Growth and Remodeling
Mechanobiology of Plants
Mechanobiology in Lower Organisms
Mechanobiology of the Heart
Mechanobiology of the Skeletal System
Mechanobiology of Connective Tissue
Other Applications to Draw Exercises From
Solutions to Exercises
Jonathan T. Butcher initiated a research program focused on understanding the roles of mechanical forces in shaping cardiovascular morphogenesis and adult disease with an emphasis on heart valves. Long term objectives to use developmental paradigms to discover novel disease paradigms and regenerative strategies. This research program focusses on the following three areas: Cardiovascular Developmental Mechanobiology; Developmental Paradigms in Postnatal Valve Disease; and Heart Valve Tissue Engineering.