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Mechanobiology of Living Systems



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ISBN 9781439806685
December 31, 2021 Forthcoming by CRC Press
700 Pages 300 B/W Illustrations

 
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Book Description

This text brings together mechanobiology theory, approaches, and applications in a format appropriate for readers with some mathematical and biological exposure. It begins by explaining fundamental mechanobiological principles in a sequential "ground up" approach that includes key terminology. Next, it identifies the in vivo mechanical environment of biological systems—highlighting areas of important research. Maintaining a focus on mechanobiology fundamentals, it includes example questions drawn from a variety of organ systems, lower organisms, and plants. This comprehensive resource includes example problems drawn from theory and applications in each chapter, as well as sections on experimental methods.

Table of Contents

Introduction
Molecular Mechanobiology
Mechanics of Adhesion and Signaling
Migration
Matrix Stiffness
Strain Based Mechanotransduction
Hemodynamics Based Signaling
Gravity
Mechanobiology of Growth and Remodeling
Mechanobiology of Plants
Mechanobiology in Lower Organisms
Mechanobiology of the Heart
Mechanobiology of the Skeletal System
Mechanobiology of Connective Tissue
Developmental Biomechanics
Other Applications to Draw Exercises From
Appendices
Solutions to Exercises

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Author(s)

Biography

Jonathan T. Butcher initiated a research program focused on understanding the roles of mechanical forces in shaping cardiovascular morphogenesis and adult disease with an emphasis on heart valves. Long term objectives to use developmental paradigms to discover novel disease paradigms and regenerative strategies. This research program focusses on the following three areas: Cardiovascular Developmental Mechanobiology; Developmental Paradigms in Postnatal Valve Disease; and Heart Valve Tissue Engineering.