Melatonin: Therapeutic Value and Neuroprotection (Hardback) book cover


Therapeutic Value and Neuroprotection

Edited by Venkatramanujan Srinivasan, Gabriella Gobbi, Samuel D. Shillcutt, Sibel Suzen

© 2014 – CRC Press

573 pages | 18 Color Illus. | 89 B/W Illus.

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Hardback: 9781482220094
pub: 2014-10-15
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pub: 2014-10-15
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About the Book

There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic potential of melatonin and melatonin agonists in treating neurodegenerative diseases and other ailments. Topics include:

  • The basic aspects of melatonin’s physiology, including its production, bioavailability, and metabolism
  • The functional importance of melatonin receptors and their role in mediating the therapeutic effectiveness of melatonin in cancer
  • Melatonin’s effect on the regulation of blood pressure, sleep, and circadian rhythms
  • The cardioprotective role of melatonin
  • The neuroprotective role in glaucoma, Alzheimer’s disease, Parkinson’s disease, and neurodegenerative diseases
  • Use as a therapeutic agent for treating epilepsy and degenerative discs
  • Treatment for obesity, diabetes mellitus, and other metabolic disorders
  • Protective role in peri-natal hypoxic-ischemia

The contributors also examine the discovery of a number of melatonergic agonists, their potential role as antioxidants, and their therapeutic applications in treating glaucoma, Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders. Opening new vistas in our understanding of etiology, pharmacotherapy, and treatment, the book is a significant milestone in our knowledge about advances in melatonin’s physiology and its therapeutic application in a number of disorders.


"This is a significant contribution to the knowledge base in melatonin physiology and its therapeutic application, written by prominent experts in the field."

—M. Isabel L. Crisostomo, MD, Rush University Medical Center in Doody’s Book Reviews

Table of Contents

Melatonin Production and Bioavailability; Emel Oyku Cetin, Yiğit Uyanıkgil, Mehmet Turgut, and Meral Baka

Deviations of Melatonin Levels and Signaling in Aging and Diseases: Options and Limits of Treatment; Rudiger Hardeland

Pineal Gland Volume and Melatonin; Niyazi Acer, Suleyman Karademir, and Mehmet Turgut

Melatonin’s Beneficial Effects in Metabolic Syndrome with Therapeutic Applications; Venkataramanujam Srinivasan, Yoshiji Ohta, Javier Espino, Rahimah Zakaria, and Mahaneem Mohamed

Therapeutic Applications of Melatonin in Pediatrics; Emilio J. Sanchez-Barcelo, Maria D. Mediavilla, and Russel J. Reiter

Neuroprotective Effect of Melatonin on Perinatal Hypoxia–Ischemia; Daniel Alonso-Alconada, Antonia Alvarez, and Enrique Hilario

Melatonin as a Therapeutic Agent for Sepsis; Edward H. Sharman and Stephen C. Bondy

Melatonin’s Cardioprotective Role; Alberto Dominguez-Rodriguez and Pedro Abreu-Gonzalez

Melatonin: Therapeutic Value and Neuroprotection in Stroke; Max Franzblau, Nick Franzese, Gabriel S. Gonzales-Portillo,

Chiara Gonzales-Portillo, Meaghan Staples, Mia C. Borlongan, Naoki Tajiri, Yuji Kaneko, and Cesar V. Borlongan

Melatonin’s Antiapoptotic Activity in Neurodegenerative Diseases; Xin Wang, Yingjun Guan, Wenyu Fu, Shuanhu Zhou, and Zheng-Hong Qin

MT2 Melatonin Receptors: Their Role in Sleep and Neuropsychiatric Disorders; Stefano Comai and Gabriella Gobbi

Melatonin: Its Hepatoprotective Actions and the Role of Melatonin Receptors; Alexander M. Mathes

Melatonin Signaling in the Control of Plasmodium Development and Replication; Alexandre Budu and Celia R. S. Garcia

Melatonin: Regulator of Adult Hippocampal Neurogenesis; Gerardo B. Ramirez-Rodriguez and Leonardo Ortiz-Lopez

Comparison of Neuroprotective Effect of Melatonin in the Nigrostriatal and Mesolimbic Dopaminergic Systems of the Zitter Rat; Shuichi Ueda, Ayuka Ehara, Kenichi Inoue, Tomoyuki Masuda, Shin-ichi Sakakibara, and Kanji Yoshimoto

Melatonin’s Neuroprotective Role in Parkinson’s Disease; Venkataramanujam Srinivasan, Timo Partonen, Mahaneem Mohamed, Rahimah Zakaria, Asma Hayati Ahmad, Charanjit Kaur, Domenico De Berardis, Edward C. Lauterbach,

Samuel D. Shillcutt, and U.S. Srinivasan

Neuroprotective Role of Melatonin in Glaucoma; Ruth E. Rosenstein, Maria C. Moreno, Pablo Sande, Marcos Aranda,

Maria F. Gonzalez Fleitas, and Nicolas Belforte

Melatonin Receptors and Their Preventive Role in Carcinogenesis; Raffaela Santoro, Maria Ferraiuolo, Giovanni Blandino, Paola Muti, and Sabrina Strano

Enhancement of Antitumor Activity of Ursolic Acid by Melatonin in Colon Cancer Cells; Wei Guo, Jingshu Wang, and Wuguo Deng

Synthetic Melatonin Receptor Ligands; Silvia Rivara, Marco Mor, Annalida Bedini, and Gilberto Spadoni

Evaluation of Synthetic Melatonin Analog Antioxidant Compounds; Sibel Suzen

Melatonin’s Analogues in Glaucoma; Hanan Awad Alkozi and Jesus Pintor

Melatonergic Drugs as Therapeutic Agents for Insomnia and Depressive Disorders; Venkataramanujam Srinivasan, Domenico De Berardis, Amnon Brzezinski, Rahimah Zakaria, Zahiruddin Othman, Samuel D. Shillcutt, Edward C. Lauterbach, Gregory M. Brown, and Timo Partonen

Agomelatine: A Neuroprotective Agent with Clinical Utility beyond Depression and Anxiety; Cecilio Alamo, Francisco Lopez-Munoz, and Pilar Garcia-Garcia

Melatonergic Antidepressant Agomelatine in Depressive and Anxiety Disorders; Domenico De Berardis, Michele Fornaro, Venkataramanujam Srinivasan, Stefano Marini, Nicola Serroni, Daniela Campanella, Gabriella Rapini, Luigi Olivieri, Felice Iasevoli, Alessandro Valchera, Giampaolo Perna, Maria Antonia Quera-Salva, Monica Mazza, Marilde Cavuto, Ida Potena, Giovanni Martinotti, and Massimo Di Giannantonio

Effects of Melatonin and Melatonergic Drugs in Transgenic Mouse Models of Alzheimer’s Disease; Beatriz B. Otalora, M. Angeles Rol, and Juan A. Madrid

Melatonin’s Mitochondrial Protective Role in Alzheimer’s Mice: Role of Melatonin Receptors; Vedad Delic and Patrick C. Bradshaw

Melatonin and Its Therapeutic Implications in Injuries of the Developing Brain and Retina; Gurugirijha Rathnasamy, Eng-Ang Ling, and Charanjit Kaur

Melatonin’s Protection against Human Prion-Mediated Neurotoxicity; Jae-Kyo Jeong and Sang-Youel Park

Melatonin’s Protection against Methamphetamine Toxicity in Neuroblastoma Cells; Banthit Chetsawang

Melatonin’s Beneficial Effects on Dopaminergic Neurons in the Rat Model of Parkinson’s Disease; Manisha Gautam, Reshu Gupta, Ravinder Kumar Saran, and Bal Krishana

Antiepileptic Effects of Melatonin; M. Hakan Seyithanoğlu, Mehmet Turgut, Meliha Gundağ Papaker, Mustafa Ayyıldız, Suleyman Kaplan, and Saffet Tuzgen

Analgesic Effects of Melatonin; Selcuk Yavuz, Mehmet Turgut, Ozlem Yalcınkaya Yavuz, and Teoman Aydın

Effects of Melatonin on the Proliferative and Differentiative Activity of Neural Stem Cells; Saime İrkoren, Heval Selman Ozkan, and Mehmet Turgut

Role of Melatonin in Collagen Synthesis; Ozgur Taşpınar, Mehmet Turgut, Engin Taştaban, and Teoman Aydın

Melatonin Use in Peripheral Nerve Injury; Mehmet Emin Onger, Suleyman Kaplan, Ebru Elibol, Omur Gulsum Deniz,

and Berrin Zuhal Altunkaynak

Neuroprotective Role of Melatonin and Its Agonists: Neuroprotective Role of Melatonin against Dexamethasone-Induced Neurotoxicity; Aziza B. Shalby and Hanaa H. Ahmed

Does Melatonin Have a Protective Role against Side Effects of Nonsteroidal Anti-Inflammatory Drugs? Ebru Elibol, Berrin Zuhal Altunkaynak, Omur Gulsum Deniz, Mehmet Emin Onger, and Suleyman Kaplan

Melatonin: Pharmacological Aspects and Clinical Trends; Emiliano Ricardo Vasconcelos Rios

Protective Effects of Melatonin in Radiation-Induced Nephrotoxicity; Eda Kucuktulu and Uzer Kucuktulu

Melatonin and Familial Mediterranean Fever; Engin Taştaban, Mehmet Turgut, and Teoman Aydın

Effects of Melatonin on Osteoblastic and Osteoclastic Activities of Bone Tissue; Meliha Gundağ Papaker, M. Hakan Seyithanoğlu, Mehmet Turgut, Suleyman Kaplan, and Saffet Tuzgen

Phyto-Melatonin: A Novel Therapeutic Aspect of Melatonin in Nature’s Way; Chandana Haldar, Somenath Ghosh, and Amaresh Kumar Singh

About the Editors

Professor Venkataramanujam Srinivasan, PhD, MAMS, started his professional career as an assistant professor at the Institute of Physiology, Madurai Medical College, Madurai, Tamil Nadu, India, where he served for 24 years. Along with teaching physiology to undergraduate medical students, he undertook various collaborative research studies with the Department of Psychiatry and published a number of papers on lithium, catecholamine metabolism, the pineal gland, and melatonin both in national and international medical and life sciences journals. He has also served as one of the advisory council members for the International Society of Psychoneuroendocrinology (ISPNE) for ten years. Professor Srinivasan then undertook teaching assignments as associate professor of physiology at the University Sains Malaysia (USM). He has collaborated on research publications with a number of professors and research scientists working in different universities internationally. Since May 2009, he has undertaken research studies on melatonin and melatonergic drugs from Sri Sathya Sai Medical Educational and Research Foundation, an international medical sciences research study center in Kovai Thirunagar, Tamil Nadu, India and has published number of papers in indexed medical journals. He also edited a book on melatonin and melatonergic drugs in clinical practice, published by Springer in February 2014.

Dr. Gabriella Gobbi is an associate professor in the Department of Psychiatry, McGill University and a staff psychiatrist at the McGill University Health Center (MUHC), Montreal, Canada. Her research interests include understanding the pathophysiology of major depression and related disorders and discovering new treatments for them. In particular, her laboratory conducts research on the short- and long-term effects of cannabis use in mood and anxiety and the potential beneficial effects of drugs acting on the endocannabinoid system (endogenous cannabis) to cure mental diseases. Her lab also conducts research on the effect of melatonin in alleviating mood disorders and anxiety, and sleep regulation in an effort to understand how novel selective ligands for melatonin receptors (called MT1 and MT2 receptors) can be used to treat seasonal depression, major depression, sleep disorders, and other neuropsychiatric conditions.

Dr. Samuel D. Shillcutt is a tenured professor and director of neuropsychopharmacology research at Mercer University School of Medicine. His research has focused on translational studies connecting interpretation of basic science and clinical trials data to lead to effective treatment modalities. His interest in understanding the pathology and treatment of neuropsychiatric disorders have led him to establishing the efficacy and safety of atypical antipsychotics, antidepressants, and medications used for Alzheimer’s disease. His research techniques involved using clinical investigation of psychopharmaceuticals, neurochemistry, and electrophysiology to determine human responses and using human tissue in cell culture to establish models for basic science investigation of potential novel compounds. His most current studies investigated the effects of melatonin-like substances in regulation of mood and sleep disorders in dementias.

Dr. Sibel Suzen is a professor of pharmaceutical chemistry at the Faculty of Pharmacy, Ankara University, and institutional coordinator of European Union (EU) student exchange programme (Erasmus Programme). She has been involved in several medicinal chemistry projects supported by the government and Ankara University. These projects are related to the synthesis and investigation of biological activity of aldose reductase inhibitory compounds, antioxidant compounds, indole derivatives, in vitro drug metabolisms by electroanalytical, and, most importantly, the synthesis and antioxidant investigation of melatonin derivatives.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Endocrinology & Metabolism
MEDICAL / Pharmacology
SCIENCE / Life Sciences / Neuroscience