Melatonin in the Promotion of Health  book cover
2nd Edition

Melatonin in the Promotion of Health

Edited By

Ronald Ross Watson

ISBN 9781138112186
Published May 31, 2017 by CRC Press
584 Pages 82 B/W Illustrations

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Book Description

Melatonin is a powerful hormone and antioxidant with numerous effects on the metabolism and the health of humans. Available as a dietary supplement in the United States since 1993, it is one of the most popular over-the-counter alternative remedies available. Comprising contributions from researchers who have studied the role of melatonin in various disease and physiological states, Melatonin in the Promotion of Health, Second Edition provides a wide variety of expert reviews on the biology of melatonin relevant to health.

Beginning with a history of melatonin and its relation to circadian rhythms, the book examines its use in a host of applications, including:

  • Gut motility and gastrointestinal diseases
  • Anesthesia and surgery
  • Bone health
  • Breast cancer
  • Cardiovascular diseases
  • Diabetes
  • Age-related macular degeneration and uveitis
  • Melanoma, solar skin damage, and collagen synthesis
  • The prevention of DNA damage
  • Mental disorders, sleep, and issues related to jet lag and shift work

The data gathered from a large number of carefully controlled animal and human studies have clearly implicated melatonin in the control mechanisms of a wide variety of physiological and psychological activities, making it a potent candidate for therapeutic use in the treatment of a diverse range of diseases. This volume demonstrates that continued studies of this molecule raise the exciting prospect of providing new avenues of treating numerous diseases more effectively and with less side-effects than those found in conventional treatment modalities.

Table of Contents

Melatonin Time Line: From Discovery to Therapy; I. Chowdhury and S. K. Maitra

Melatonin and Circadian Rhythms: An Overview; G. C. Verster

Synthesis and Metabolism of Melatonin in the Skin and Retinal Pigment Epithelium; Radomir Slominski and Andrzej Slominski

Melatonin in Prevention of Mutagenesis, Oxidation, and Other Damage to Cells; Theodore Lialiaris

Cardiovascular Protection by Melatonin; Rita Rezzani

Melatonin Effect on Reproduction; Maria P. Tsantarliotou and Ioannis A. Taitzoglou

Melatonin and the Prevention of Ultraviolet Solar Skin Damage; Tobias W. Fischer

Melatonin and Type 2 Diabetes; Andreas Gunter Bach and Elmar Peschke

Melatonin, Sleep, and Immune Modulation: Role in Health and Disease; Daniel P. Cardinali

Melatonin as a Treatment for Uveitis; Ruth E. Rosenstein, Pablo H. Sande, Diego C. Fernandez, Mónica Chianelli, and Daniel A. Sáenz

Role of Melatonin in Regulating Gut Motility; Jennie Wong and Khek-Yu Ho

Melatonin and Food Safety: Investigating a Possible Role in the Seasonality of the Bacterial Pathogen Escherichia coli O157:H7 in Cattle; Tom S. Edrington and David J. Nisbet

Melatonin in Dentistry; Luigi F. Rodella, Mauro Labanca, and Eleonora Foglio

Melatonin as a Potential Treatment of Gastrointestinal Diseases; George A. Bubenik

The Uses of Melatonin in Anesthesia and Surgery; Hany A. Mowafi and Salah A. Ismail

Melatonin in Bone Health; Paula A. Witt-Enderby, William P. Clafshenkel, Mary P. Kotlarczyk, and Shalini Sethi

Prevention and Treatment of Breast Cancer Using Melatonin; Vicki L. Davis, Balasunder R. Dodda, and Paula A. Witt-Enderby

Molecular and Epigenetic Effects of Melatonin in Breast Cancer; S. Proietti, A. Cucina, S. Dinicola, A. Pasqualato, F. D’Anselmi, and M. Bizzarri

Melatonin in Mental Disorders: Treatment and Prevention; Maria D. Maldonado and Maria A. Pérez-San-Gregorio

Melatonin in Control of Gastric Secretion and Prevention of Gastric Mucosal Lesions; Peter C. Konturek, Iwona Brzozowska, Krzysztof Celinski, Stanislaw J. Konturek, and Tomasz Brzozowski

Melatonin for the Control of Reproduction in Small Ruminants; L. A. Zarazaga, J. L. Guzmán, and B. Malpaux

Melatonin in the Pancreatic Protection and Modulation of Pancreatic Exocrine Secretion; Jolanta Jaworek

Life Environment and Sleep: Melatonin Production Affected by Light and Ambient Temperature in Humans; Masayuki Kondo and Tomoko Wakamura

Decreased Light Transmittance Because of Aging and Melatonin; Takeshi Morita

Melatonin and Treatment of Disorders Related to Jet Lag and Shift Work; Gregory M. Brown, Seithikurippu R. Pandi- Perumal, Ilya Trakht, D. Warren Spence, Daniel P. Cardinali, and Alexander Samel

Melatonin and Its Byproducts on Age-Related Macular Degeneration; Dan-Ning Hu, Joan E. Roberts, and Richard B. Rosen

Melatonin and Melanoma; Dan-Ning Hu, Joan E. Roberts, and Allan F. Wiechmann

Melatonin and Inflammation—The Role of the Immune–Pineal Axis and the Sympathetic Tonus; Pedro A. Fernandes, and Regina P. Markus

Neuroendocrinological Effects of Antidepressants: Is There a Role for Melatonin?; Marco Antonioli, Joanna Rybka, and Livia A. Carvalho

Role of Melatonin in Collagen Synthesis; John Tidwell and Ming Pei

Melatonin and DNA Protection; Luis Sarabia, Carlos Ponce, Maria Jose Munuce, and Hector Rodriguez

Melatonin Modulation of Vascular Structure and Function; Mustafa Yildiz

Melatonin and Sleep Disturbances in Patients with End-Stage Renal Disease; Birgit Koch, Marije Russcher, and Elsbeth Nagtegaal

Melatonin and Traumatic Stress; Petr Bob

Measurement of Melatonin in Other Body Fluids; Soyhan Bağcı

Cell Studies with Melatonin Exposed to UV Light and Ionizing Radiation; Ilona Izykowska, Marek Cegielski, and Piotr Dziegiel

Melatonin and Oxidation; V. Haktan Ozacmak

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Ronald R. Watson, PhD, is a member of several national and international nutrition, immunology, cancer, and alcoholism research societies. For 30 years he was funded by Wallace Research Foundation to study dietary supplements in health promotion. Dr. Watson has edited more than 35 books on nutrition, dietary supplements, and over-the-counter agents, and 53 other scientific books. He has published more than 500 research and review articles.