Metabolic & Therapeutic Aspects of Amino Acids in Clinical Nutrition: 2nd Edition (Hardback) book cover

Metabolic & Therapeutic Aspects of Amino Acids in Clinical Nutrition

2nd Edition

Edited by Luc A. Cynober

CRC Press

776 pages | 70 B/W Illus.

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Hardback: 9780849313820
pub: 2003-11-13
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The first edition of this innovative book brought a new perspective to the metabolic and therapeutic aspects of amino acids in clinical nutrition. Since its publication, a number of very important advances have been made in the field and interesting new findings have emerged. Until now, no reference has fully explored the promising new developments and applications in this key area of clinical nutrition.

Completely revised and updated, Metabolic and Therapeutic Aspects of Amino Acids in Clinical Nutrition, Second Edition presents current information and discussions on amino acid metabolism in various health and nutritional states. Chapters cover amino acid uptake routes, physiology, requirements, metabolism, and applications. Written by an international group of experts, the text re-evaluates data and hypotheses in light of the most recent discoveries in genomics and proteomics research.

Building on the solid foundation of the original reference, the second edition refines much of the previous information and features the fresh insight and ideas of new authors. These timely additions on the role of amino acids in the future of human health and disease ensure that this book will continue to be a standard resource for researchers in this field.


"…explains excellently the metabolism of amino acids and discusses if for different health and nutritional conditions. This book will be found very useful for persons carrying out research in this field."

- Carbohydrate Polymers 64, (2006) 138-143

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Table of Contents

Introduction, J.M. Kinney



Measurement of amino acid concentrations in biological fluids and tissues using ion exchange chromatography, N. Neveux, P. David, and L. Cynober

Measurement of amino acid concentrations in biological fluids and tissues using reversed-phase HPLC-based methods, B. Alteheld, P. Stehle, and P. Fürst

Approaches to studying amino acid metabolism: from quantitative assays to flux assessment using stable isotopes, D. Darmaun and L. Cynober

Cellular uptake of amino acids: systems and regulation, V. Ganapathy, K. Inoue, P. D. Prasad, and E. Ganapathy


Section A: Metabolism

Amino acid metabolism and gluconeogenesis, X. Leverve

Contribution of amino acids to ketogenesis, M. Holecek

Ureagenesis and ammoniagenesis: an update, A.J. Meijer

Metabolism of branched-chain amino acids, A.J.M. Wagenmakers

The glutamate crossway, Y. Wakabayashi

Arginine metabolism in mammals, G. Wu and S.M. Morris Jr.

Glutamine metabolism, R. Oehler and E. Roth

Section B: Control of and by amino acids

Insulin and the regulation of amino acid catabolism and protein turnover, J.P. De Bandt

Control of amino acid metabolism by counter-regulatory hormones, J. Wernerman

Nitric oxide, E.J. Mahoney and J.E. Albina

Control of amino acid metabolism by lipid, ketone bodies and glucose substrates, Y. Boirie, S. Walrand and B. Beaufrère

Amino acid signaling and the control of protein metabolism, A.J. Meijer and P. F. Dubbelhuis

The role of amino acids in the control of proteolysis, S. vom Dahl and D. Häussinger

Anabolic effects and signaling pathways triggered by amino acids in the liver, L. Hue and L. Bertrand

Amino acids and immune function, P. Calder and P. Yaqoob

Amino acid mediated insulin secretion, W.J. Malaisse

Part III: Amino Acid Metabolism in Disease

Cancer-associated cachexia: altered metabolism of protein and amino acids, M. Mackenzie and V.E. Baracos

Diabetes Mellitus, K. Dhatariya and K.S. Nair

Acidosis and Amino acid metabolism, T. Welbourne and I. Nissim

Muscle protein and amino acid metabolism with respect to age-related sarcopenia, S. Walrand and Y. Boirie

Gastrointestinal diseases, P.B. Soeters, K.W. Hussewe, N.E.P. Deutz, Y. Luiking, and C.H.C. Dejong

Amino acids and ammonia in liver disease, C.H.C. Dejong, S.W.M. Olde Damink, R. Jalan, N.E.P. Deutz, and P.B. Soeters


Part IV: Amino acid requirements

Nutritional essentiality of amino acids and amino acid requirements in healthy adults, V.R . Young and J.F. Tharakan

Neonatal requirements for amino acids, D.K. Rassin

Amino acids requirements in the elderly, P. Patureau-Mirand, L. Mosoni, and D. Rémond

Amino acid requirements in sport, M. Gleeson and A.E. Jeukendrup


Section A: Quantitative and qualitative aspects

Quantitative and qualitative amino acid intake by the parenteral route, G. Iapichino, D. Radrizzani and L.A. Cynober

Quantitative and qualitative aspects of nitrogen supply in enteral nutrition in relation to free amino acids and peptides, G.K. Grimble

Branched-chain amino and keto acids in renal failure, N. Cano

Glutamine supplemented diets in enteral nutrition, P.G. Boelens and P. van Leeuwen

The use of arginine in clinical practice, N.N. Abumrad and A. Barbul

Glutamine and glutamine-containing dipeptides, P. Fürst and P. Stehle

Ornithine a-ketoglutarate, L.A. Cynober

Section B: Formulas devoted to specific situations

Amino acid support in patients with catabolic illness, N.M. Daignault, D.P. Griffith, T.V. Nattakom, and T.R. Ziegler

Sulfur containing amino acid and glutathione in diseases, C. Obled, I. Papet, and D. Breuillé

Amino acid requirement in cancer, M. Muscaritoli, F.R. Fanelli, M.M. Meguid, and A.C.L. Campos

Amino acid solutions for acute renal failure, C.J. Foulks

Amino acids to support gut function and morphology, G.S. Sacks and K.A. Kudsk

Section C: Nutraceutics

L-Arginine-enriched diets in cardiovascular diseases, M. Collin and H. Vapaatalo

Taurine homeostasis and its importance for physiological functions, S.H. Hansen


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
MEDICAL / Nutrition