Metal Ions in Biological Systems
Volume 33: Probing of Nucleic Acids by Metal Ion Complexes of Small Molecules
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"Volume 33 focuses on the vibrant research area of probing nucleic acids--the carriers of the genetic code--by metal ion complexes of small molecules providing an authoritative, timely account of this fascinating topic by over 50 distinguished experts."
Table of Contents
Molecular modelling of transition metal adducts with nucleic acids and their constituents; zinc complexes as targeting agents for nucleic acids; metallocene interactions with DNA and DNA processing enzymes; evidences for a catalytic activity of the DNA double helix in the reactions between DNA, platinum (II) and intercalators; trans-diammineplatinum (II) - what makes it different from CIS-DDP? coordination chemistry of a neglected relative of cisplatin and its interaction with nucleic acids; metal ions in multiple-stranded DNA; DNA interactions with substitution-intert transition metal ion complexes; effect of metal ions on the fluorescence of dyes bound to DNA; photolytic covalent binding of metal complexes to DNA; electrochemically activated nucleic acid oxidation; electron transfer between metal complexes bound to DNA - is DNA a wire?; porphyrin and metalloporphyrin interactions with DNA; selective DNA cleavage by metalloporphyrin derivatives; synthetic metalloporphyrins as probes of protein-DNA interactions; targeting of nucleic acids by iron complexes; nucleic acid chemistry of the cuprous complexes of 1,10-phenanthroline and derivatives; specific DNA cleavage by manganese (III) complexes; nickel complexes as probes of guanine sites in nucleic acid folding; hydrolytic cleavage of RNA catalyzed by metal ion complexes; RNA recognition and cleavage by iron (III)-bleomycin; metallobleomycin-DNA interactions - structures and reactions related to bleomycin-induced DNA damage.
". . .draws on the experience of recognized international experts to review the present status of research in this area. . . . . .a very useful volume, complementing Volume 32. . .recommended to all those with an interest in this area of bioinorganic chemistry. "
---Platinum Metals Review