1st Edition

Metal Ions in Biological Systems Volume 9: Amino Acids and Derivatives as Ambivalent Ligands

Edited By Helmut Sigel Copyright 1979
    302 Pages
    by CRC Press

    This book focuses on the connection between the chemistry of metal ions and their role for life, and covers complexes with a number of amino acids with chelatable side chain donor atoms. It discusses metal ion-protein interactions and the ligating ambivalency of nucleotides.

    Preface to the Series
    Preface to Volume 9
    Contents of other Volumes
    Chapter 1
    Complexes of a-Amino Acids with Chelatable Side Chain Donor Atoms
    R. Bruce Martin
    1. Scope
    2. Stability Constant Comparisons
    3. Asparagine and Glutamine
    4. Serine and Threonine
    5. Methionine and S-Methylcysteine
    6. Cystine
    7. a, w-Diaminocarboxylates
    8. Histidine
    9. Aromatic Side Chains
    Chapter 2
    Metal Comlexes of Aspartic Acid and Glutamic Acid
    Christopher A. Evans, Roger Guevremont, and Dallas L. Rabenstein
    1 Introduction
    2 Acid-Base Chemistry
    3 Comlexes with Main Group Metal Ions
    4 Complexes with Transition Metals
    5 Comlexes with Lanthanides and Actinides
    Abbreviations and Defintions
    Chapter 3
    The Coordination Chemistry of L-Cysteine and D-Penicillamine
    A. Gergely and I. Sovago
    1. Introduction
    2. Properties of Ligands
    3. Complexes of Nontransition Elements
    4. Complexes of the Transition Metals
    5. Mixed Ligand Complexes
    6. Conclusion
    Chapter 4
    Glutathinone and It’s Metal Complexes
    Dallas L. Rabenstein, Roger Guevremont, and Christopher A. Evans
    1 Introduction
    2 Redox Chemistry of Glutathinone
    3 Acid-Base Chemistry of Glutathinone
    4 Coordination Chemistry of Reduced Glutathione
    5. Coordination Chemistry of Oxidized Glutathinone
    6. Summary
    Abbreviations and Definitions
    Chapter 5
    Coordination Chemistry of L-Dopa and Related Ligands
    A. Gergely and T. Kiss
    1. Introduction
    2. Chemical Characteristics of L-Dopa and Related Ligands
    3. Metal Complexes of the Ligands
    4. Implication of Metal Ions and Their Complexes in Biological Functions of Catecholamines
    5. Conclusions
    Chapter 6
    Stereoselectivity in the Metal Complexes of Amino Acids and Dipeptides
    Leslie D. Pettit and Robert J. W. Hefford
    1 Introduction
    2 Amino Acid Complexes
    3 Dipeptide Complexes
    Chapter 7
    Protonation and Complexation of Macromolecular Polypeptides: Corticortropin Fragments and Basic Trypsin Inhibitor (Kunitz Base)
    Kalman Burger
    1 Introduction
    2 Protonation Equilibria
    3 Complex Formation Equilibria
    4 Conclusion
    Author Index
    Subject Index


    Helmut Sigel