1st Edition

Metal Nanocomposites in Nanotherapeutics for Oxidative Stress-Induced Metabolic Disorders

Edited By Anindita Behera Copyright 2024
    438 Pages 49 Color & 1 B/W Illustrations
    by CRC Press

    438 Pages 49 Color & 1 B/W Illustrations
    by CRC Press

    This book highlights the role and mechanism of different metal nanocomposites toward oxidative stress-induced metabolic disorders including metabolic pathways affected by oxidative stress and related pathophysiology. The book includes an illustrative discussion about the methods of synthesis, characterization, and biomedical applications of metal nanocomposites. It focuses on the therapeutic approaches for metabolic disorders due to oxidative stress by nano delivery systems. Moreover, the book includes chapters on nanotherapeutic approaches toward different diseases, including diabetes mellitus, obesity, cardiovascular disorders, cancers, and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. This book is aimed at researchers and graduate students in nanocomposites, nano delivery systems, and bioengineering.


    • Discusses nanocomposites in the field of therapy for diabetes, obesity, cardiovascular disorders, neurodegenerative diseases, and cancers
    • Details the pathophysiology of oxidative stress-induced metabolic disorder
    • Explains mechanisms of the antioxidant potential of metal nanocomposites
    • Discusses pathways to elucidate the therapeutic activity
    • Reviews specific and precise applications of metal nanocomposites against lifestyle-induced disorders


    Chapter 1. Oxidative stress-induced metabolic disorders: Mechanism and pathogenesis
    1.1. Introduction
    1.2. Metabolic diseases and oxidative stress
    1.3. Oxidative stress and metabolic disorder leading to diabetes
    1.4. Oxidative stress leading to CVD
    1.5. Oxidative stress resulting in carcinogenesis
    1.6. Oxidative stress leading to obesity
    1.7. Conclusion and Future Prospects

    Chapter 2. Metal nanocomposites: synthesis, characterization, and biomedical applications
    2.1. Introduction
    2.2. Historical Background
    2.3. Properties of Nanocomposites
    2.4. Classification of Nanocomposites
    2.5. Emerging trends in the Metal Oxide nanocomposites
    2.6. Fabrication of the Metal Oxide Nanocomposites
    2.7. Characterization of the fabricated Metal Oxide Nanocomposites
    2.8. Factors influencing the fabrication and characterization of Metal Oxide Nanocomposites
    2.9. Biomedical applications of the Metal Oxide Nanocomposites in oxidative stress-induced disorders
    2.10. Challenges and Limitations of the Metal Oxide Nanocomposites
    2.11. Conclusion and Future perspectives

    Chapter 3. The general concept of metal nanocomposites in nanotherapeutics against oxidative stress-induced metabolic disorders
    3.1. Nanotherapeutics and Nanocomposites
    3.2. Oxidative stress (OS)-induced metabolic disorders (MD)
    3.3. Role of metal nanocomposites in theranostic and management of OS-induced metabolic disorders
    3.4. Conclusion and future perspectives of MNCs

    Chapter 4. Nanotherapeutics for leptin resistance and obesity using metal nanocomposites
    4.1. Introduction
    4.2. Pathophysiology of leptin resistance and obesity
    4.3. Relation between oxidative stress and Obesity
    4.4. Pharmacological Treatment of Obesity and challenges
    4.5. Theranostic applications of metal nanocomposites in leptin resistance and obesity
    4.6. Conclusion and future perspectives

    Chapter 5. Nanotherapeutics for insulin resistance and diabetes mellitus using metal nanocomposites
    5.1 Diabetes Mellitus (DM) and Insulin Resistance
    5.2 Mechanisms of Insulin Resistance and Diabetes caused by Oxidative Stress
    5.3 Diagnosis of Diabetes Mellitus
    5.4 Metal-based Nanosensors in Diagnosis of Diabetes Mellitus
    5.5 Treatment of Diabetes Mellitus and Insulin Resistance
    5.6 Conclusion and Future prospectives

    Chapter 6. Nanotherapeutics for diabetic retinopathy with metal nanocomposites
    6.1. Introduction
    6.2. Anatomy and Physiology of Retina
    6.3. Pathophysiology of Diabetic Retinopathy
    6.4. Treatment
    6.5. Drawbacks of conventional therapy
    6.6. Metal nanocomposites
    6.7. Applications of Metal nanocomposites in DR
    6.8. Recent advances and future perspectives
    6.9. Conclusions

    Chapter 7. Nanotherapeutics for diabetic nephropathy with metal nanocomposites
    7.1. Introduction
    7.2. Metal nanocomposites in diabetic nephropathy
    7.3. Future perspectives
    7.4. Conclusion

    Chapter 8. Nanotherapeutics for diabetic cardiomyopathy using metal nanocomposites
    8.1. Introduction
    8.2. Signaling pathways of DCM
    8.3. Current therapeutic implications and challenges in DCM
    8.4. Nanomaterials as drug therapy for diabetic cardiomyopathy
    8.5. Recent trends in the treatment of DCM with nanocomposites
    8.6. Challenges, Limitations, and Future Prospectives
    8.7. Conclusion

    Chapter 9. Nanotherapeutics for a diabetic foot ulcer and wound healing with metal nanocomposites

    9.1. Diabetic foot ulcer and wound healing
    9.2. Design of metal nanocomposites and their applications in wound healing
    9.3. Biocompatibility of metal nanocomposites
    9.4. Patents on metal nanocomposites for DFU and wound healing
    9.5. Current challenges and prospects
    9.6. Conclusion

    Chapter 10. Nanotherapeutics for management of dyslipidemia
    10.1. Introduction
    10.2. Etiopathogenesis of dyslipidemia
    10.3. Management of dyslipidemia
    10.4. Plant-based drugs for dyslipidemia
    10.5. Nanotherapeutics for dyslipidaemia
    10.6. ROS-based nanotherapeutics against dyslipidaemia
    10.7. Conclusion

    Chapter 11. Nanotherapeutics for endometrial cancer with metal nanocomposites
    11.1 Introduction
    11.2 Molecular mechnism of endometrial cancer
    11.3 Recent Difficulties in Endometrial Cancer Treatment
    11.4 Future Treatment Approaches in Endometrial Cancer: Metalloproteinase Inhibitors
    11.5 Nanomedicines and cancer treatments based on glycans

    11.6 Nanocomposites of Polymers and Metals in the Treatment of Endometrial Cancer
    11.7 Conclusion

    Chapter 12. Nanotherapeutics for colorectal cancer using metal nanocomposites
    12.1. Introduction
    12.2. Cancer Cell Biology: Exploiting Deviant Physiological Features
    12.3. Metal/Carbon Nanoparticles in Microbot/Nanobot design
    12.4. Synthetic Strategies for Nanocomposites
    12.5. Colorectal Cancer Models
    12.6. Strategies of Colorectal Cancer Cell/Tumor Targeting
    12.7. Conclusions and Path Forward

    Chapter 13. Nanotherapeutics for ovarian cancer using metal nanocomposites

    13.1. Introduction
    13.2. Pathogenesis of Ovarian cancer
    13.3. Challenges with current therapy for ovarian cancer treatment
    13.4. Classification and Applications of metal nanocomposites
    13.5. Benefits of metal nanocomposites in treating ovarian cancer
    13.6. Challenges in using metal nanocomposites for ovarian cancer
    13.7. Adverse effects/toxicities associated with the use of metal nanocomposites
    13.8. Conclusion and Future Perspectives

    Chapter 14. Nanotherapeutics for breast cancer using metal nanocomposites
    14.1. Introduction
    14.2. Conventional treatment for breast cancer
    14.3. Nanotechnology-based approaches to treat breast cancer
    14.4. Different nano-formulations for the Therapy of breast cancer
    14.5. Metal Nanocomposites for Breast Cancer
    14.6. Role of metal nanocomposites in breast cancer treatment
    14.7. Conclusion

    Chapter 15. Nanotherapeutics for liver cancer with metal nanocomposites
    15.1. Introduction
    15.2. Biocompatibility and Toxicity of Nanocomposites
    15.3. Nano-antioxidants
    15.4. Macromolecular Nanocomposites
    15.5. Targeting Nanocomposites to HCC
    15.6. Nanocomposites in the Therapy of HCC
    15.7. Limitations of Nanocomposites
    15.8. Conclusions

    Chapter 16. Nanotherapeutics for reversal against multidrug resistance in chemotherapy with metal nanocomposites
    16.1 Introduction
    16.2 Nanotherapeutics
    16.3 Metal Nanocomposites
    16.4 Metal Oxide Nanocomposites:
    16.5 Conclusion

    Chapter 17. Nanotherapeutics for Alzheimer’s disease using metal nanocomposites
    17.1. Introduction
    17.2. Role of Metal nanocomposites in neurodegeneration: From inception to treatment
    17.3. Metal nanocomposites utilized in the detection and treatment of Alzheimer's disease
    17.4. Conclusion

    Chapter 18. Nanotherapeutics for PD using metal nanocomposites
    18.1. Background
    18.2. Pathophysiology of PD
    18.3. Current therapeutics for PD
    18.4. Nanotherapeutics: A promising approach in the treament of PD

    18.5. Applications of metal nanocomposites for PD
    18.6. Conclusion


    Anindita Behera is an Associate Professor, Department of Pharmaceutical Analysis, Siksha ‘O’ Anusandhan Deemed to be University. She did her masters from Pune University, India, and Ph.D. from Siksha ‘O’ Anusandhan Deemed to be University. She has developed new analytical methods for drug formulations used in the treatment of AIDS. Currently, she is involved in the green synthesis of nanomaterial targeting different life-risk diseases. She has more than 15 years of experience in research and academics. She has published several research and review articles in peer-reviewed journals. She has also contributed many book chapters to books published with other leading publishers. She has guided two Ph.D. scholars; eleven post-graduate scholars and 30 undergraduate students.