Metastatic Diseases: Novel Approaches in Diagnosis and Therapeutic Management opens new horizons for exploring modern therapeutic entities and emerging targets for combating the deadly disease of cancer. The authors provide a review of cancer along with descriptions of its molecular level mechanisms and emphasize the role of promising new therapies, including herbal therapies that can be utilized for the treatment of metastatic diseases. The chapters look at specific approaches that have been researched and developed and that have almost reached the standardization stage. One of the approaches focuses on intracellular mechanisms, particularly proteins, and the pathway involving or being regulated by the proteins that limit the metastatic cellular growths. In particular phosphoprotein enriched astrocytes are being extensively tried. Also discussed is transerythretin protein, which has been significantly studied for its involvement in formation and transportation of proteins in metastatic diseases. Other receptors and approaches examined include CXCR4, autophagy-inhibiting drugs, phosphoprotein-enriched astrocytes, spatiotemporal genetic analysis, tyrosine kinase inhibitors, and more.
Table of Contents
1. A Review on Cancer: From Clinical Perspective to Chemotherapy 2. Phosphoprotein-Enriched Astrocytes as Potential Anti-Cancer Agents 3. Autophagy-Inhibiting Drugs as Complements to Cancer Chemotherapy 4. Transthyretin Protein in Renowned Metastatic and Other Conditions 5. Role of CXCR4 Receptor Protein in Cancer Development and Therapies 6. C3d Complement System in Immunotherapy-Based Cancer Treatment 7. BH3 Mimetics 8. Spherical Nucleic Acid Platform Based Drug Delivery for Brain Cancer and Improved Blood Brain Barrier Crossing for Alzheimer’s and Other Diseases 9. Intra-Vital Microscopy: A New Amelioration in Cancer Immunotherapy Monitoring 10. Molecular Imaging: A New Advancement in Cancer Immunotherapy Monitoring 11. Spatiotemporal Genetic Analysis (SaGA) Technique for Cancer Cell Biology Studies 12. Plant-Derived Anti-Malarial Compounds and Their Derivatives as Anti-Cancer Agents: Future Perspectives 13. Epigenetic Control of the Immune System 14. Immune Check Point Inhibitors 15. Tyrosine Kinase Inhibitors in Lymphocytic Leukemia 16. Cyclooxygenase – 1 (COX-1) Inhibitors in the Management of Neoplastic Disorders 17. Microfluidics Devices in Capturing Circulating Metastatic Cancer Cell Clusters
Sandeep Arora, PhD, is Director of the Chitkara Institute of Pharmaceutical Sciences and Professor, Healthcare Rajpura Campus, in Punjab, India.
Tapan Behl, PhD, MPharm, is currently working as an Associate Professor in the Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.
Sukhbir Singh, PhD, is an Associate Professor at Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Neelam Sharma, PhD, is an Associate Professor at Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Saurabh Gupta, PhD, is Associate Head of the Department of Pharmacology at Chitkara College of Pharmacy, Chitkara University, India.