Methods in Microarray Normalization  book cover
SAVE
$17.69
1st Edition

Methods in Microarray Normalization

Edited By

Phillip Stafford




ISBN 9780429140525
Published January 31, 2008 by CRC Press
304 Pages

FREE Standard Shipping

What are VitalSource eBooks?




Prices & shipping based on shipping country


Preview

Book Description

Scientists can use molecular profiling microarrays to compare healthy cells with their diseased counterparts and develop gene-specific treatments. Finding the best way to interpret original profiling data into accurate trends, however, continues to drive the development of normalization algorithms and software tools.

Methods in Microarray Normalization compiles the most useful and novel techniques for the first time into a single, organized source. Experts in the field provide a diverse view of the mathematical processes that are important in normalizing data and avoiding inherent systematic biases. They also review useful software, including discussions on key algorithms, comparative data, and download locations.

The book discusses the use of early normalization techniques for new profiling methods and includes strategies for assessing the utility of various normalization algorithms. It presents the latest microarray innovations from companies such as Agilent, Affymetrix, and GeneGo as well as new normalization methods for protein and CGH arrays, many of which are applicable for antibody, microRNA, methylation, and siRNA arrays.

Methods in Microarray Normalization provides scientists with a complete resource on the most effective tools available for maximizing microarray data in biochemical research.

Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

Table of Contents

A comprehensive analysis of the effect of microarray data preprocessing methods on differentially expressed transcript selection. Differentiation detection in microarray normalization. Preprocessing and normalization for affymetrix genechip expression microarrays. Spatial detrending and normalization methods for two-channel DNA and protein microarray data. A survey of cDNA microarray normalization and a comparison by k-NN classification. Technical variation in modeling the joint expression of several genes. Biological interpretation for microarray normalization selection. Methodology of functional analysis for omics data normalization. Exon array analysis for the detection of alternative splicing. Normalization of array CGH data. SNP array-based analysis for detection of chromosomal aberrations and copy number variations. Index.

...
View More

Reviews

"Methods in Microarray Normalization compiles the most useful and novel techniques for the first time into a single, organized source. Experts in the field provide a diverse view of the mathematical processes that are important in normalizing data and avoiding inherent systematic biases."

– In Anticancer Research, July/August 2008, Vol. 28, No. 4A