Micro Reaction Technology in Organic Synthesis: 1st Edition (Hardback) book cover

Micro Reaction Technology in Organic Synthesis

1st Edition

By Charlotte Wiles, Paul Watts

CRC Press

453 pages | 327 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9781439824719
pub: 2011-03-15
SAVE ~$36.00
eBook (VitalSource) : 9780429093135
pub: 2016-04-19
from $28.98

FREE Standard Shipping!


While continuous processes have found widespread application within chemical production, members of the research and development communities have historically favored the centuries old technique of iterative batch reactions. With the exception of combinatorial and microwave chemistry, little had been done to change the way that synthetic chemists conduct their research. However, today’s synthetic chemist is under increasing pressure to discover and deliver compounds quickly, with an eye on devising scalable synthetic methodologies.

An up-to-date account of recent developments in continuous flow organic synthesis, Micro Reaction Technology in Organic Synthesis is a useful resource for those both new to, and actively researching within, the field of micro reaction technology.

  • Written by chemists for chemists, key synthetic information takes precedence over technological details
  • Highlights the advantages and disadvantages of the technology, giving the reader an idea of where future research needs to be targeted
  • Presents a comprehensive collection of synthetic reactions that have been investigated over the past decade, therefore is a one-stop resource to the reactions and techniques that have been investigated so far

With an ever increasing number of commercial flow reaction platforms available, this book highlights the current state of the technology with the vision that more synthetic chemists will embark upon flow chemistry programs of research, facilitating the identification of novel synthetic methodologies the potential to be scaled directly to production.


"Although there have been several books devoted to Micro Reaction Technology over the past decade, there has not been a volume focussed on the needs of the organic chemist. This excellent new book fulfils that gap."

—Trevor Laird, in Organic Process Research, March 2011

"In contrast to some of the other books available on this subject, this is clearly a book written by chemists for chemists. In a relatively short and easy-to-follow introductory chapter, the fundamentals of micro reaction technology, including fabrication of devices, pumping and mixing issues, and advantages/disadvantages, are explained with the synthetic chemist in mind. In each of tile sub chapters, the reader is pointed toward appropriate key references, review articles, or other books that provide further details on the subject."

American Chemical Society, 2011

Table of Contents

Introduction to Micro Reaction Technology

What is Micro Reaction Technology?

Fabrication/Construction of Micro Reactors

Manipulation of Reactants and Products within Flow Reactors

Advantages of Micro Reaction Technology

Disadvantages of Micro Reactors

Process Intensification

In Situ Reaction Monitoring

Commercial Availability of Continuous Flow



Micro Reactions Employing a Gaseous Component

Gas-Phase Micro Reactions

Gas–Liquid-Phase Micro Reactions

Gas–Liquid–Solid Micro Reactions


Liquid-Phase Micro Reactions

Nucleophilic Substitution

Electrophilic Substitution

Nucleophilic Addition

Elimination Reactions



Metal-Catalyzed Cross-Coupling Reactions


Multistep/Multicomponent Liquid-Phase Reactions



Multi-Phase Micro Reactions

Nucleophilic Substitution

Electrophilic Substitution

Nucleophilic Addition

Elimination Reactions

Oxidation Reactions

Metal-Catalyzed Cross-Coupling Reactions


Enantioselective Reactions

Multistep/Multicomponent Reactions



Electrochemical and Photochemical Applications of Micro Reaction Technology

Electrochemical Synthesis under Continuous Flow

Photochemical Synthesis under Continuous Flow

Multiphase Photochemical Reactions


The Use of Microfluidic Devices for the Preparation and Manipulation of Droplets and Inorganic/Organic Particles

Droplet Formation using Continuous Flow Methodology

Preparation of Inorganic Nanoparticles under Continuous Processing Conditions

Formation of Organic Particles within Continuous Flow Devices

The Use of Micro Reactors for the Postsynthetic Manipulation of Organic Compounds

Mixed Particle Formation



Industrial Interest in Micro Reaction Technology

MRT in Production Environments

Synthesis of Fine Chemicals Using Micro Reactors

Synthesis of Pharmaceuticals and Natural Products using Continuous Flow Methodology

Synthesis of Small Doses of Radiopharmaceuticals



Microscale Continuous Separations and Purifications


Liquid–Liquid Extractions

Gas–Liquid Separation

Solvent Exchange and Solvent Removal

The Use of Scavenger Resins for Product Purification under Flow

Continuous Flow Resolutions

Product Isolation



Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Chemistry / General
SCIENCE / Chemistry / Organic
SCIENCE / Chemistry / Industrial & Technical
TECHNOLOGY & ENGINEERING / Environmental / General