1st Edition

Micro Reaction Technology in Organic Synthesis




ISBN 9781439824719
Published March 15, 2011 by CRC Press
462 Pages 327 B/W Illustrations

USD $190.00

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Book Description

While continuous processes have found widespread application within chemical production, members of the research and development communities have historically favored the centuries old technique of iterative batch reactions. With the exception of combinatorial and microwave chemistry, little had been done to change the way that synthetic chemists conduct their research. However, today’s synthetic chemist is under increasing pressure to discover and deliver compounds quickly, with an eye on devising scalable synthetic methodologies.

An up-to-date account of recent developments in continuous flow organic synthesis, Micro Reaction Technology in Organic Synthesis is a useful resource for those both new to, and actively researching within, the field of micro reaction technology.

  • Written by chemists for chemists, key synthetic information takes precedence over technological details
  • Highlights the advantages and disadvantages of the technology, giving the reader an idea of where future research needs to be targeted
  • Presents a comprehensive collection of synthetic reactions that have been investigated over the past decade, therefore is a one-stop resource to the reactions and techniques that have been investigated so far

With an ever increasing number of commercial flow reaction platforms available, this book highlights the current state of the technology with the vision that more synthetic chemists will embark upon flow chemistry programs of research, facilitating the identification of novel synthetic methodologies the potential to be scaled directly to production.

Table of Contents

Introduction to Micro Reaction Technology
What is Micro Reaction Technology?
Fabrication/Construction of Micro Reactors
Manipulation of Reactants and Products within Flow Reactors
Advantages of Micro Reaction Technology
Disadvantages of Micro Reactors
Process Intensification
In Situ Reaction Monitoring
Commercial Availability of Continuous Flow
Outlook
References

Micro Reactions Employing a Gaseous Component

Gas-Phase Micro Reactions
Gas–Liquid-Phase Micro Reactions
Gas–Liquid–Solid Micro Reactions
References

Liquid-Phase Micro Reactions

Nucleophilic Substitution
Electrophilic Substitution
Nucleophilic Addition
Elimination Reactions
Oxidations
Reductions
Metal-Catalyzed Cross-Coupling Reactions
Rearrangements
Multistep/Multicomponent Liquid-Phase Reactions
Summary
References

Multi-Phase Micro Reactions

Nucleophilic Substitution
Electrophilic Substitution
Nucleophilic Addition
Elimination Reactions
Oxidation Reactions
Metal-Catalyzed Cross-Coupling Reactions
Rearrangements
Enantioselective Reactions
Multistep/Multicomponent Reactions
Summary
References

Electrochemical and Photochemical Applications of Micro Reaction Technology
Electrochemical Synthesis under Continuous Flow
Photochemical Synthesis under Continuous Flow
Multiphase Photochemical Reactions
References

The Use of Microfluidic Devices for the Preparation and Manipulation of Droplets and Inorganic/Organic Particles
Droplet Formation using Continuous Flow Methodology
Preparation of Inorganic Nanoparticles under Continuous Processing Conditions
Formation of Organic Particles within Continuous Flow Devices
The Use of Micro Reactors for the Postsynthetic Manipulation of Organic Compounds
Mixed Particle Formation
Summary
References

Industrial Interest in Micro Reaction Technology

MRT in Production Environments
Synthesis of Fine Chemicals Using Micro Reactors
Synthesis of Pharmaceuticals and Natural Products using Continuous Flow Methodology
Synthesis of Small Doses of Radiopharmaceuticals
Summary
References

Microscale Continuous Separations and Purifications

Introduction
Liquid–Liquid Extractions
Gas–Liquid Separation
Solvent Exchange and Solvent Removal
The Use of Scavenger Resins for Product Purification under Flow
Continuous Flow Resolutions
Product Isolation
Summary
References

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Reviews

"Although there have been several books devoted to Micro Reaction Technology over the past decade, there has not been a volume focussed on the needs of the organic chemist. This excellent new book fulfils that gap."
—Trevor Laird, in Organic Process Research, March 2011

"In contrast to some of the other books available on this subject, this is clearly a book written by chemists for chemists. In a relatively short and easy-to-follow introductory chapter, the fundamentals of micro reaction technology, including fabrication of devices, pumping and mixing issues, and advantages/disadvantages, are explained with the synthetic chemist in mind. In each of tile sub chapters, the reader is pointed toward appropriate key references, review articles, or other books that provide further details on the subject."
American Chemical Society, 2011