Jenny Stanford Publishing
This book presents current advances in the emerging interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology, and mathematical modeling. This volume contains adaptations and critical reviews of recent state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. Interactions with transcription factor regulatory networks and mathematical modeling of microRNA regulation are also discussed.
Measurement and Interpretation of MiRNA Expression Profiles. MicroRNA Expression Analysis by LNA Enhanced Microarrays. Analysis and QC for Real-Time QPCR Arrays of Human MicroRNAs. Massively Parallel MicroRNA Profiling in the Haematologic Malignancies. Who Dunit? MicroRNAs Involved in Prostate Cancer. Intronic MicroRNA. Creation, Evolution and Regulation. Mirome Architecture and Genomic Instability. Interconnection of MicroRNA and Transcription Factor-Mediated Regulatory Networks. Analysis of MicroRNA Profiling Data with Systems Biology Tools. Mathematical and Computational Modeling of Post-Transcriptional Gene Regulation by MicroRNAs.