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Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery




ISBN 9781574445725
Published November 1, 2005 by CRC Press
528 Pages - 4 Color & 325 B/W Illustrations

 
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Book Description

The microfluidic lab-on-a-chip allows scientists to conduct chemical and biochemical analysis in a miniaturized format so small that properties and effects are successfully enhanced, and processes seamlessly integrated. This microscale advantage translates into greater sensitivity, more accurate results, and better information.

Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery focuses on all aspects of the microfluidic lab-on-a-chip technologies and offers an overview of the available technology, its limitations, and its breakthroughs over the years. It emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods, microfluidic operations, chemical separations, sample preparation and injection methods, detection technology, and various chemical and biological analyses. Other topics of interest include the use of polymeric chips, fluid flow valve and control, single-cell analysis, DNA and RNA amplification techniques, DNA hybridization, immunoassays and enzymatic assays.

Originally conceived as a single chapter published in Ewing's Analytical Instrumentation, this book is a gateway to the vast literature and conference proceedings on the topic. Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery expands upon its roots to present a comprehensive treatment of microfluidic lab-on-a-chip methods and applications for novices and advanced researchers alike.

Table of Contents

Introduction

Micromachining Methods
Micromachining of Silicon
Micromachining of Glass
Micromachining of Fused Quartz (or Fused Silica)
Micromachining of Polymeric Chips
Metal Patterning
World-to-Chip Interface

Microfluidic Flow
Liquid Pumping Methods
Microfluidic Flow Control


Sample Introduction
Electrokinetic Injection
Hydrodynamic Injection
Other Sample Injection Methods

Sample Pre-concentration
Sample Stacking
Extraction
Porous Membrane
Other Pre-concentration Methods

Separation
Gas Chromatography (GC)
Capillary Electrophoresis (CE)
Chromatographic Separations
Coupled Separations

Detection Methods
Optical Detection Methods
Electrochemical (EC) Detection
Mass Spectrometry (MS)
Other Detection Methods

Applications to Cellular/Particle Analysis
Retention of Cells and Particles
Studies of Cells in a Flow
Other Cell Operations

Applications to Nucleic Acids Analysis
Nucleic Acids Extraction and Purification
Nucleic Acids Amplification
DNA Hybridization
Other Nucleic Acid Applications

Applications to Protein Analysis
Immunoassay
Protein Separation
Enzymatic Assays

Appendix

Problem Sets
Introduction
Micromachining
Microfluidic Flow
Sample Introduction
Sample Preconcentration
Separation
Detection
Cellular Analysis
Nucleic Acid Analysis
Protein Analysis
References
Glossary

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Author(s)

Biography

Paul C.H. Li

Reviews

"…truly an awesome book…This well-documented book with a multitude of references: 1/178 references are integrated throughout the book…well-written and compares well to other science books of its kind…a great book to learn about instrument design, with numerous pictures and illustrations making the text much easier to understand. Good pictures are something that is lacking in all too many science books."
-Gary S. Vardon, Salt Lake Tribune, in Journal of Materials

"In fact I can say that it is an excellent book, well thought out and written."

– P. Myers, in Chromatographia, June 2007, Vol. 65