530 pages | 10 Color Illus. | 78 B/W Illus.
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Mitochondria—Reactive Oxygen Species (ROS)—Cell Death
A Healthy Free Radical Pessimism: A Glance from an Oxidative Lipidomics Corner; V. E. Kagan, A. A. Shvedova, and Y. Y. Tyurina
Mitochondrial Involvement in the Execution of Cell Death; V. Gogvadze, B. Zhivotovsky, and S. Orrenius
The Role of Protein Kinase C in Mitochondrial Functions in Cardiac Ischemia- Reperfusion Injury; J. C. B. Ferreira and D. Mochly-Rosen
Mitocans, Mitochondria-Targeting Anticancer Drugs: Focus on Mitochondrial Complexes; J. Neuzil, L.-F. Dong, and J. Rohlena
Therapeutic Potential of Lipoamide and Enhanced Mitochondrial Biogenesis for Treatment of Insulin Resistance; W. Shen, D. A. Carlson, L. Packer, E. Cadenas, and J. Liu
Mitochondria-Targeted Antioxidants; R. A. J. Smith, R. C. Hartley, and M. P. Murphy
Lactate Shuttling and the Mitochondrial Lactate Oxidation Complex; G. A. Brooks
Nitric Oxide in the Regulation of Mitochondrial Biogenesis; C. De Palma and E. Clementi
Effect of Sildenafil on Heart Nitric Oxide Metabolism and Mitochondrial Function; T. Zaobornyj, L. B. Valdez, and A. Boveris
Kinases and Mitochondrial Cycling: The Last Encounter; M. C. Carreras and J. J. Poderoso
Nuclear Chromatin Factors Defining Mitochondrial Bioenergetics: Implications in Age-Associated Diseases; P. Puigserver and L. Guarente
Mitochondrial Protein Acetylation and Sirtuin-Mediated Deacetylation; L. Valente, R. Szklarczyk, M. A. Huynen, and J. N. Spelbrink
Mitochondrial Regulation by Protein Acetylation; D. B. Lombard, D. X. Tishkoff, and B. M. M.
Calorie Restriction, Mitochondria, and Longevity in Saccharomyces cerevisiae; C. Skinner and S.-J. Lin
Autophagy and Aging: Keeping Organelles and the Proteome Healthy; J. L. Schneider and A. M. Cuervo
Mitochondrial Dynamics and Its Implications in Metabolic Dysregulation and Neurodegeneration; A. Zorzano, J. Segalés, M. I. Hernández-Alvarez, and E. Sorianello
Mitochondrial Abnormalities and Oxidative Stress in Alzheimer’s Disease: Can Mitochondrial Reactive Oxygen Species Signaling Promote Neuronal Survival? P. I. Moreira and C. R. Oliveira
The Role of Mitochondria in Parkinson’s Disease and Huntington’s Disease; A. H. V. Schapira
α-Ketoglutarate Dehydrogenase Complex in Neurodegeneration; G. E. Gibson, A. Starkov, Q. Shi, and M. Flint Beal
R-α-Lipoic Acid as a Potent Agent of Mitochondrial Protection in Alzheimer’s Disease; D. J. Bonda, M. A. Smith, G. Perry, H.-g. Lee, X. Wang, and X. Zhu
Mitochondrial Antioxidants in Neuroprotection; G. Fiskum and M. D. Laird