Molecular Biology : Structure and Dynamics of Genomes and Proteomes book cover
1st Edition

Molecular Biology
Structure and Dynamics of Genomes and Proteomes

ISBN 9780815345046
Published November 23, 2015 by Garland Science
648 Pages 650 B/W Illustrations

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Book Description

Recipient of the CHOICE Outstanding Academic Title (OAT) Award.

Molecular Biology: Structure and Dynamics of Genomes and Proteomes illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins.

This textbook emphasizes the experimental basis of discovery and the most recent advances in the field while presenting a structural, mechanistic understanding of molecular biology that is rigorous, yet concise. The text is written for advanced undergraduate or graduate-level courses in molecular biology.

Molecular Biology: Structure and Dynamics of Genomes and Proteomes is additionally supported by the Garland Science Learning System. This homework platform is designed to evaluate and improve student performance and allows instructors to select assignments on specific topics and review the performance of the entire class, as well as individual students, via the instructor dashboard. Students receive immediate feedback on their mastery of the topics, and will be better prepared for lectures and classroom discussions. The user-friendly system provides a convenient way to engage students while assessing progress. Performance data can be used to tailor classroom discussion, activities, and lectures to address students’ needs precisely and efficiently.

A free trial for the Garland Science Learning System will be available to use during the Spring and Fall 2017 semesters. For more information and to sign up for access, visit

Table of Contents

Chapter 1: To the Cell and Beyond: The Realm of Molecular Biology
Chapter 2: From Classical Genetics to Molecular Genetics
Chapter 3: Proteins
Chapter 4: Nucleic Acids
Chapter 5: Recombinant DNA: Principles and Applications
Chapter 6: Protein-Nucleic Acid Interactions
Chapter 7: The Genetic Code, Genes, and Genomes
Chapter 8: Physical Structure of the Genomic Material
Chapter 9: Transcription in Bacteria
Chapter 10: Transcription in Eukaryotes
Chapter 11: Regulation of Transcription in Bacteria
Chapter 12: Regulation of Transcription in Eukaryotes
Chapter 13: Transcription Regulation in the Human Genome
Chapter 14: RNA Processing
Chapter 15: Translation: The Players
Chapter 16: Translation: The Process
Chapter 17: Regulation of Translation
Chapter 18: Protein Processing and Modification
Chapter 19: DNA Replication in Bacteria
Chapter 20: DNA Replication in Eukaryotes
Chapter 21: DNA Recombination
Chapter 22: DNA Repair

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Jordanka Zlatanova is Professor Emeritus in the Department of Molecular Biology at the University of Wyoming.  She earned her PhD and DSc degrees in cellular and molecular biology from the Bulgarian Academy of Sciences, conducting experiments at the Ernst Boehringer Institute for Drug Research in Vienna, Austria.  Zlatanova was Department Head of the Molecular Genetics at the Institute of Genetics in the Bulgarian Academy of Sciences before becoming a Senior Research Professor at Oregon State University.  She was also Deputy Director of the Biochip Center at Argonne National Laboratory and a Professor in the Department of Chemical and Biological Sciences and Engineering at Polytechnic University in Brooklyn, NY.  Zlatanova is a member of the Bulgarian Union of Scientists, Biochemistry and Biophysics Section, the Austrian Biochemical Society, and the International Society for Plant Molecular Biology and was the recipient of an International Cancer Research Technology Transfer (ICRETT) Award.  She has authored over 150 papers and numerous books and book chapters.  Her research interests are in chromatin structure and dynamics and its role in transcription regulation.

Kensal E. van Holde is Distinguished Professor Emeritus in the Department of Biochemistry and Biophysics at Oregon State University. He earned his PhD in physical chemistry at the University of Wisconsin, Madison.  After working as an industrial chemist, he returned to academia and in 1967, he joined the Department of Biochemistry and Biophysics at Oregon State University, reflecting his evolving interests from polymer chemistry to biology.  van Holde has won numerous teaching and education awards, and is a fellow of the American Association for the Advancement of Science (AAAS) and member of the American Academy of Arts and Sciences and the National Academy of Science. His research has focused on the structure and function of oxygen transport proteins and the structure of chromatin.  He is among the world's leading experts in biophysical chemistry and is the author of multiple textbooks. 


"The authors draw a seamless connection between the classical molecular and cell biology techniques and numerous recent advances…[Their] efforts toward inculcating a sense of history in every discovery and concept is nailed in every chapter."
- The Yale Journal of Biology and Medicine, December 2016, Volume 89, Issue 4