Molecular Biology of Alzheimer's Disease: Genes and Mechanisms Involved in Amyloid Generation, 1st Edition (Hardback) book cover

Molecular Biology of Alzheimer's Disease

Genes and Mechanisms Involved in Amyloid Generation, 1st Edition

Edited by Christian Haass

CRC Press

330 pages

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Hardback: 9789057023811
pub: 1999-01-18
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Description

Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.

Table of Contents

1. The Tau Proteins in Alzheimer's Disease 2. The Genetics of Familial Alzheimer's Disease 3. Mutations in Three Genes Are Associated with Early Onset Alzheimer's Disease 4. The Molecular Biology of Presenilin 1 5. Molecular Biology of Presenilin 2 6. Presenilin Proteins and Their Role in Development and Notch Signaling 7. Transgenic Animal Models in the Development of Therapeutic Strategies for Alzheimer's Disease 8. Amyloid Morphology and Pathology of Alzheimer's Disease 9. The Biological Activities and Function of the Amyloid Precursor Protein of Alzheimer's Disease 10. Transgenic Models of Alzheimer's Disease

Subject Categories

BISAC Subject Codes/Headings:
MED032000
MEDICAL / Geriatrics
MED056000
MEDICAL / Neurology
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology
SCI086000
SCIENCE / Life Sciences / General