Molecular Immunological Considerations in Malaria Vaccine Development: 1st Edition (Hardback) book cover

Molecular Immunological Considerations in Malaria Vaccine Development

1st Edition

By Michael F. Good, Allan J. Saul

CRC Press

288 pages

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Hardback: 9780849352584
pub: 1993-10-13
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Some of the world's leading research scientists in the field have contributed to this new book on malaria vaccine development. The book examines various strategies being pursued against the different stages of the parasite (the sporozoite, asexual erythrocytic stages, and sexual stages). It describes vaccines that combat the parasite directly, vaccines aimed at preventing disease, vaccines based on attenuated parasites, and vaccines based on small, carefully defined synthetic peptides. The book provides a compendium of current approaches, lists of preferred antigens, and the results of vaccine trials to date. Molecular immunology involved with both the natural immune response to parasites and with the constraints on inducing immunity are emphasized throughout the book. Views on how vaccines may be tested and then integrated into malaria control programs are also discussed. Molecular Immunological Considerations in Malaria Vaccine Development will be useful for researchers and students in immunology, parasitology, biotechnology, vaccine design, and tropical and public health.

Table of Contents

Malaria Immunity: An Overview with Emphasis on T Cell Function, M. Troye-Blomberg and P. Perlmann

The Role of Cytokine-Activated Phagocytic Cells in Immunity to Malaria, A. Ferrante, L.M. Kumaratilake, and D.A. Rathjen

Rodent Malarias: Lessons for Human Malaria Vaccines, S. Kumar, G. Milon, and L.H. Miller

T Cell Memory and the Spleen: Major Considerations in a Vaccine Strategy for Inducing Cellular Immunity, M.F. Good

Prospects of an Anti-Disease Vaccine, D. Kwiatkowski

Preerythrocytic Malaria Vaccine Development, S.L. Hoffman, E.D. Franke, W.O. Rogers, and S. Mellouk

Candidate Antigens for an Asexual Blood-Stage Vaccine against Falciparum Malaria, R.F. Anders and A.J. Saul

Progress Toward a Transmission-Blocking Vaccine, D.C. Kaslow

Testing the Vaccine, A.J. Saul

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Immunology
MEDICAL / Pharmacology