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Garland Science
500 pages | 512 Color Illus.
Viruses interact with host cells in ways that uniquely reveal a great deal about general aspects of molecular and cellular structure and function. Molecular and Cellular Biology of Viruses leads students on an exploration of viruses by supporting engaging and interactive learning. All the major classes of viruses are covered, with separate chapters for their replication and expression strategies, and chapters for mechanisms such as attachment that are independent of the virus genome type. Specific cases drawn from primary literature foster student engagement. End-of-chapter questions focus on analysis and interpretation with answers being given on the website (half for students, all for instructors). Examples come from the most-studied and medically important viruses such as HIV, influenza, and poliovirus. Plant viruses and bacteriophages are also included. There are chapters on the overall effect of viral infection on the host cell. Coverage of the immune system is focused on the interplay between host defenses and viruses, with a separate chapter on medical applications such as anti-viral drugs and vaccine development. The final chapter is on virus diversity and evolution, incorporating contemporary insights from metagenomic research.
Key selling feature:
1. The Fundamentals of Molecular and Cellular Virology
2. The Virus Replication Cycle
3. Attachment, Penetration, and Uncoating
4. Gene Expression and Genome Replication in Model Bacteriophages
5. Gene Expression and Genome Replication in Positive Strand RNA Viruses
6. Gene Expression and Genome Replication in the Negative Strand RNA Viruses
7. Gene Expression and Genome Replication in the Double-Stranded RNA Viruses
8. Gene Expression and Genome Replication in the Double-Stranded RNA Viruses
9. Gene Expression and Genome Replication in the Single-Stranded DNA Viruses
10. Gene Expression and Genome Replication in the Retroviruses and Hepadnaviruses
11. Assembly, Maturation & Release
12. Virus-Host Interactions During Lytic Growth
13. Persistent Viral Infections
14. Innate Host Defenses and Viral Strategies that Evade Them
15. Adaptive Host Defenses and Viral Strategies that Evade Them
16. Medical Applications of Molecular and Cellular Virology
17. Viral Diversity, Origins, and Evolution
