Molecular and Cellular Biophysics: 1st Edition (Hardback) book cover

Molecular and Cellular Biophysics

1st Edition

By Jack A. Tuszynski

Chapman and Hall/CRC

544 pages | 10 Color Illus. | 216 B/W Illus.

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Hardback: 9781584886754
pub: 2007-10-11
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Description

From quantum theory to statistical mechanics, the methodologies of physics are often used to explain some of life's most complex biological problems. Exploring this challenging yet fascinating area of study, Molecular and Cellular Biophysics covers both molecular and cellular structures as well as the biophysical processes that occur in these structures. Designed for advanced undergraduate and beginning graduate students in biophysics courses, this textbook features a quantitative approach that avoids being too abstract in its presentation.

Logically organized from small-scale (molecular) to large-scale (cellular) systems, the text first defines life, discussing the scientific controversies between mechanists and vitalists, the characteristics of living things, and the evolution of life. It then delves into molecular structures, including nucleic acids, DNA, RNA, interatomic interactions, and hydrogen bonds. After looking at these smaller systems, the author probes the larger cellular structures. He examines the cytoplasm, the cytoskeleton, chromosomes, mitochondria, motor proteins, and more. The book concludes with discussions on biophysical processes, including oxidative phosphorylation, diffusion, bioenergetics, conformational transitions in proteins, vesicle transport, subcellular structure formation, and cell division.

Reviews

"…The processes of life do have characteristics that are not easily understood in terms of equilibrium or rate equations, powerful though those ideas are, and Tuszynski’s book gives a valuable reminder of this wealth of behaviours. In other words, it is a very stimulating book, and one that research scientists should read because it will surprise them, usually in ways they will welcome. It is also the sort of book graduate students should read to prevent them getting too lost in the routine of technique."

—Marshall Stoneham, Contemporary Physics, Vol. 50, No. 3, May–June 2009

Table of Contents

WHAT IS LIFE?

Hierarchical Organization of Knowledge

General Characteristics of Living Systems

Artificial Life

Biological Information, Information Processing, and Signaling

Origin of Life

Emergence, Intelligence, and Consciousness

WHAT ARE THE MOLECULES OF LIFE?

Nucleic Acids, DNA, RNA

Generalized Ester Bonds

Directionality of Chemical Bonds

Types of Interatomic Interactions

The Hydrogen Bonds and Hydrophobic Interactions

Amphipatic Molecules in Water Environments

Structure of Proteins

Structure of Nucleic Acids

WHAT IS A BIOLOGICAL CELL?

Cytoplasm

Cytoskeleton

Tubulin Isotype Homology Modeling

Anisotropic Elastic Properties of Microtubules

Centrioles, Basal Bodies, Cilia, and Flagella

Networks and Meshworks of Protein Filaments, Stress Fibers, and Tensegrity

Cell Nucleus and Chromosomes

Mitochondria and Proton Pumps: Energy Generation and Utilization in the Cell

Cytochrome Oxidase Enzymes

Membranes and Vesicles

Motor Proteins and Their Role in Cellular Processes

Directed Binding as a Model of Kinesin Walk

Other Structures

Large Polar Molecules

WHAT ARE LIFE PROCESSES?

Oxidative Phosphorylation

Diffusion Processes

Proton Transport and Bioenergetics

Electronic and Ionic Conductivities of Microtubules and Actin Filaments

Mechanisms of Exciton Energy Transfer in Scheibe Aggregates

Conformational Transitions in Proteins

Vesicle Transport and Molecular Motors

Muscle Contraction

Subcellular Structure Formation

Cell Division

GLOSSARY

INDEX

Questions, Problems, and References appear at the end of each chapter.

About the Series

Pure and Applied Physics

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Subject Categories

BISAC Subject Codes/Headings:
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology
SCI055000
SCIENCE / Physics
TEC003000
TECHNOLOGY & ENGINEERING / Agriculture / General