First Published in 1995: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.
Table of Contents
Mechanisms of Toxicity
1. Aspects of Selectivity and Mechanism in Neurotoxicity
W. N. Aldridge
2. Injury and Repair in Neurotoxicology
3. Toxicity of Oxygen
Donald J. Reed
Margaret M. Manson
5. Experimental Studies with Fibers
J.M.G. Davis and R.C. Brown
Biomonitoring and Molecular Interactions in Carcinogenesis
6. Biomonitoring and Molecular Dosimetry of Genotoxic Carcinogens
7. The Relationship of Molecular Interactions with DNA to Cancer: Scientific Developments
Genetic and Cellular Aspects in Toxicology
8. The Study of Genes and Gene Expression by In Situ Hybridization: A Potentially Useful Approach in Toxicology
9. Genetic Variation in Human and Laboratory Animal Populations and Its Implications for Toxicological Research and Human Risk Assessment
Michael F. W. Festing
10. Mechanisms of Cell Death, with Particular Reference to Apoptosis
Gerald M. Cohen et al.
11. Apoptosis: Some Aspects of Regulation and Role in Carcinogenesis
Francesco De Matteis is a Professor at the Institute of Pharmacology, University of Turin, Italy.
Lewis L. Smith is a Professor at the MRC Toxicology Unit, University of Leicester, England.