1st Edition

Molecular and Cellular Mechanisms of Toxicity

ISBN 9780367229122
Published June 12, 2019 by CRC Press
224 Pages

USD $200.00

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Book Description

First Published in 1995: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.

Table of Contents

Mechanisms of Toxicity

1. Aspects of Selectivity and Mechanism in Neurotoxicity

W. N. Aldridge

2. Injury and Repair in Neurotoxicology

Marcello Lotti

3. Toxicity of Oxygen

Donald J. Reed

4. Aflatoxins

Margaret M. Manson

5. Experimental Studies with Fibers

J.M.G. Davis and R.C. Brown

Biomonitoring and Molecular Interactions in Carcinogenesis

6. Biomonitoring and Molecular Dosimetry of Genotoxic Carcinogens

Peter Farmer

7. The Relationship of Molecular Interactions with DNA to Cancer: Scientific Developments

P.N. Magee

Genetic and Cellular Aspects in Toxicology

8. The Study of Genes and Gene Expression by In Situ Hybridization: A Potentially Useful Approach in Toxicology

Ian Lauder

9. Genetic Variation in Human and Laboratory Animal Populations and Its Implications for Toxicological Research and Human Risk Assessment

Michael F. W. Festing

10. Mechanisms of Cell Death, with Particular Reference to Apoptosis

Gerald M. Cohen et al.

11. Apoptosis: Some Aspects of Regulation and Role in Carcinogenesis

Rolf Schulte-Hermann


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Francesco De Matteis is a Professor at the Institute of Pharmacology, University of Turin, Italy.

Lewis L. Smith is a Professor at the MRC Toxicology Unit, University of Leicester, England.