Monoamine Oxidase Inhibitors in Neurological Diseases  book cover
1st Edition

Monoamine Oxidase Inhibitors in Neurological Diseases

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ISBN 9780824790820
Published January 12, 1994 by CRC Press
400 Pages

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Book Description

Emphasizing the role of monoamine oxidase (MAO) in the etiology and pathogenesis of Parkinson's disease and Alzheimer's disease, this up-to-date reference describes the genetics, physiology, biochemistry, pharmacology, and clinical aspects of this very important class of enzymes.

Details how the interaction between selegiline (deprenyl) and MAO may retard the progression of neurodegenerative disorders!

Providing the latest theories on how selegiline operates, Monoamine Oxidase Inhibitors in Neurological Diseases

  • presents fundamental information on MAO types A and B
  • examines the distribution of MAO A and B in the normal human brain
  • investigates the effects of disease and aging on MAO A and B
  • analyzes a critical role for MAO in the toxic action in Parkinson's disease
  • elucidates selegiline's novel ability to delay the progression or repair the damage of dopaminergic neurons
  • discusses the usefulness of MAO inhibitors in psychiatric disease
  • and more!
  • Table of Contents

    The Distribution of Monoamine Oxidases A and B in Normal Human Brain, Karin N. Westlund
    Effects of Disease and Aging on Monoamine Oxidases A and B, Manfred Gerlach, Peter Riederer, and Moussa B. H. Youdim
    Biochemistry and Mechanism of Action of Monoamine Oxidases A and B, Eimear M. O'Brien and Keith F. Tipton
    The Structure, Gene, and Promoter Organization of Monoamine Oxidases A and B, Jean Chen Shih, Kevin Chen, Joseph S. Grimsby, Qin-Shi Zhu, and Timothy K. Gallaher
    Molecular Genetics and Inheritance of Human Monoamine Oxidases A and B, Xandra O. Breakefield, Zheng-Yi Chen, Elizabeth Tivol, Christo Shalish, and Ian W. Craig
    Role of Monoamine Oxidase Genetics in the Etiology of Parkinson's Disease, Janice H. Kurth and Matthias C. Kurth
    Multiple Forms of Monoamine Oxidase and Iron: Their Relevance to the Pathology and Treatment of Parkinson's Disease, Moussa B. H. Youdim, Dorit Ben-Shachar, and Peter Riederer
    A Critical Role for Monoamine Oxidase in Toxin Action in Parkinson's Disease, Peter Jenner
    Effects of Monoamine Oxidase B Inhibitors on Dopaminergic Function: Role of 2-Phenylethylamine and Aromatic L-Amino Acid Decarboxylase, Augusto V. Juorio, Xin-Min Li, I. A. Paterson, and Alan A. Boulton
    Inhibition of Monoamine Oxidase B and the Neuroprotective Effects of Selegiline, Kevin T. Finnegan
    Reduction of Nerve Cell Death by Deprenyl Without Monoamine Oxidase Inhibition, William G. Tatton, Nadine A. Seniuk, William Y. H. Ju, and Karen S. Ansari
    Monoamine Oxidase Inhibitors as Neuroprotective Therapy, Warren Olanow and Donald B. Calne
    Selegiline as Symptomatic Treatment for Parkinson's Disease, Abraham Lieberman
    Monoamine Oxidase Inhibitors in Alzheimer's Disease, Jody Corey-Bloom and Leon J. Thal
    Role of Monoamine Oxidase Inhibitors in Psychiatry, David J. Houlihan and Samuel Gershon

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    This book represents a good review of this subject.
    "-Neurological Research