With the recent discovery of JAK2 mutations in myeloproliferative disorders, medical science has taken a revolutionary stride forward toward understanding the pathogenesis of these diseases. This new advancement translates not only to a more rapid and reliable diagnosis, but also allows groundbreaking research into the development of new therapeutics. Written in an easy-to-follow text myeloproliferative disorders gives the practicing clinician a single source answer to classification, diagnosis, management, and recent advances in this disorder.
Preface. Modern classification and diagnostic algorithms in myeloproliferative disorders. Diagnostic utility of bone marrow pathology in myeloproliferative disorders. Molecular pathogenesis of BCR/ABL-negative myeloproliferative disorders. Cytogenetic studies in myeloproliferative disorders. Congenital causes of erythrocytosis and thrombocytosis. Management of polycythemia vera. Management of essential thrombocythemia. Management of myelofibrosis with myeloid metaplasia. Contemporary diagnosis and management of systemic mastocytosis. Modern classification and treatment of primary eosinophilic disorders. Overlap MDS/MPD.