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NMR in Drug Design



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ISBN 9780849378249
Published December 18, 1995 by CRC Press
496 Pages

 
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Book Description

NMR in Drug Design discusses the use of nuclear magnetic resonance (NMR) in studies of the design, structure, mechanism, and actions of pharmaceutical agents. Topics include rational drug design, NMR techniques in drug design, conformational analysis by NMR, macromolecular structure determination, protein-ligand interactions, drug-DNA interactions, and studies of enzyme mechanisms by NMR. This reference book provides invaluable practical information to the scientist working in drug design or NMR research.

Table of Contents

Drug Design and Discovery: Where Next? P.R . Andrews
The Role of NMR in Drug Design and Development, D.J. Craik
Studies of Drug-Receptor Interactions by NMR: Theory and Applications, J.T. Gerig
Protein Structure Determination Using NMR Spectroscopy, G.F. King and J.P. Mackay
Conformational Analysis of Drug Molecules, J.W. Jaroszewski
Conformational Analysis of Peptides: Application to Drug Design, H. Kessler, R.K. Konat, and W. Schmitt
Protein-Ligand Interactions: Examples in Drug Design, R.M. Cooke
NMR Studies of Ligand Binding to Dihydrofolate Reductase and Their Application in Drug Design, J. Feeney
Studies of Drug-Calmodulin Binding Using Isotopically Labelled Protein, D.G . Reid, A.J. Edwards, and P.J. Sweeney
Flexibility and Function in the HIV-1 Protease, L.K. Nicholson, C.-H. Chang, and C.N. Hodge
DNA as a Target for Drug Action: Complexes of Intercalating Antibiotics, M.S. Searle
Drug Binding to the Minor Groove of DNA, D.J. Craik, S. Pavlopoulos, and G. Wickham

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