NMR in Drug Design: 1st Edition (Hardback) book cover

NMR in Drug Design

1st Edition

Edited by David J. Craik

CRC Press

496 pages

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Hardback: 9780849378249
pub: 1995-12-18
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Description

NMR in Drug Design discusses the use of nuclear magnetic resonance (NMR) in studies of the design, structure, mechanism, and actions of pharmaceutical agents. Topics include rational drug design, NMR techniques in drug design, conformational analysis by NMR, macromolecular structure determination, protein-ligand interactions, drug-DNA interactions, and studies of enzyme mechanisms by NMR. This reference book provides invaluable practical information to the scientist working in drug design or NMR research.

Table of Contents

Drug Design and Discovery: Where Next? P.R . Andrews

The Role of NMR in Drug Design and Development, D.J. Craik

Studies of Drug-Receptor Interactions by NMR: Theory and Applications, J.T. Gerig

Protein Structure Determination Using NMR Spectroscopy, G.F. King and J.P. Mackay

Conformational Analysis of Drug Molecules, J.W. Jaroszewski

Conformational Analysis of Peptides: Application to Drug Design, H. Kessler, R.K. Konat, and W. Schmitt

Protein-Ligand Interactions: Examples in Drug Design, R.M. Cooke

NMR Studies of Ligand Binding to Dihydrofolate Reductase and Their Application in Drug Design, J. Feeney

Studies of Drug-Calmodulin Binding Using Isotopically Labelled Protein, D.G . Reid, A.J. Edwards, and P.J. Sweeney

Flexibility and Function in the HIV-1 Protease, L.K. Nicholson, C.-H. Chang, and C.N. Hodge

DNA as a Target for Drug Action: Complexes of Intercalating Antibiotics, M.S. Searle

Drug Binding to the Minor Groove of DNA, D.J. Craik, S. Pavlopoulos, and G. Wickham

About the Series

Advances in Analytical Biotechnology

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Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology