Nanostructures and Nanoconstructions based on DNA: 1st Edition (Hardback) book cover

Nanostructures and Nanoconstructions based on DNA

1st Edition

By Yuri M. Yevdokimov, V.I. Salyanov, S.G. Skuridin

CRC Press

250 pages | 26 Color Illus. | 129 B/W Illus.

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pub: 2012-06-04
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Description

Evolutionally optimized biomolecules and their complexes present attractive objects in the production of functionalized nanoobjects. Indeed, nucleic acid-based molecules are primary candidates as building blocks for development of nanoscale systems and devices.

Written for chemists, physicists, molecular biologists, and students in related fields, Nanostructures and Nanoconstructions Based on DNA covers specific properties of metallic nanoparticles, and compares their properties with those related to nanoobjects formed by biological molecules. It also discloses details of formation and physicochemical peculiarities of the DNA nanostructures and DNA-based nanoconstructions. Furthermore, the book considers:

  • The peculiarities of two approaches to structural DNA nanotechnology, i.e. to creation of spatial nanoobjects formed by DNA molecules and their complexes: (i) the hybridization approach and (ii) the liquid-crystalline approach
  • The physicochemical properties of DNA nanostructures as well as "liquid" and "rigid" DNA-based nanoconstructions
  • The connection of liquid crystalline phase formation in DNA with possible nanotechnological applications

This timely reference covers more DNA physics and molecular biology than any other published title. The authors discuss how nucleic acid molecules and their complexes with chemical and biologically active compounds are an area of increasing significance in the development of various nanoscale systems and devices of practical importance.

Table of Contents

Nanoparticles and Biological Molecules

Metal Nanoparticles and Their Properties

Biological Molecules: A New Background for the Creation of Nanoobjects

Organization of Research in Nanotechnology Area

The Health Risk of Nanomaterials

Nanostructures Formed by Hybridization of Synthetic Single- Stranded DNA Molecules

General Concept of the Fundamental Properties of DNA Used in Nanotechnology

Hybridization Technique of Creating Nanostructures Based on Synthetic Single-Stranded DNA Molecules (Bottom-Up Approach to the Creation of DNA Nanostructures)

Organic Linker Molecules as Rigid "Vertices" in the Tailored Spatial DNA Nanostructures Formed by Hybridization Technique

Arrangement of Objects on the Surface of DNA Nanostructures

"Liquid" Nanoconstructions Based on Spatially Ordered Double-Stranded DNA Molecules

Double-Stranded DNA Molecules as Building Blocks for Nanotechnology

Phase Exclusion of Double-Stranded DNA Molecules from Polyethylene Glycol Solutions

The Cholesteric Mode of Nucleic Acid Molecules Packing in Particles of Dispersions Results in an Appearance of Abnormal CD Spectra

Accumulation of the "Guest" Molecules in the DNA Molecules Forming CLCD Particles

"Rigid" Nanoconstructions Based by Spatially Ordered Double-Stranded DNA Molecules Complexed with Various Compounds and Nanoparticles

Backgrounds for Formation of Rigid DNA Nanoconstructions

Rigid Nanoconstructions Formed as a Result of Formation of Nanobridges between Neighboring DNA Molecules Fixed in Quasinematic Layers

The Magnetometric Evaluation of Cu2+ Ions in the Content of Nanobridges Formed between Spatially Fixed DNA Molecules

Visualization of Rigid DNA Nanoconstructions Linked with Nanobridges and Manipulations with These Nanoconstructions

Dependence of Optical Properties of DNA Nanoconstructions on Temperature

Rigid Nanoconstruction Formed as a Result of Formation of Complexes of DNA Molecules Fixed in Quasinematic Layers with Rare-Earth Metal Cations

Visualization of Rigid Particles of Cholesteric Liquid-Crystalline Dispersion of a [DNA-Gd3+] Complex

Au Nanoparticles Can Induce Formation of Rigid DNA Nanoconstruction

An Additional Case: Formation of Semi-Rigid Liquid-Crystalline Particles

Viral Particles as "Rigid" Biological Nanoconstructions: Their Creation and Medical Application Prospects

D. Yu. Logunov, B. S. Naroditsky, and A. L. Gintsburg

A "PEG-Like Situation" in Biological Systems and Peculiarities of Biological Nanoconstructions

Methods for Obtaining Recombinant Adenovirus "Rigid" Nanostructures

Recombinant Adenovirus Nanostructures with a Modified Genome

Replication-Competent Recombinant Adenovirus Nanostructures

Replication-Incompetent Recombinant Adenovirus Nanostructures

Capsid-Modified Recombinant Adenovirus Nanostructures

Physicochemical Modifications of Recombinant Adenovirus Particles

Application of Recombinant Adenovirus Nanostructures in Medicine

Application of "Liquid" and "Rigid" DNA Nanoconstructions Immobilized in Polymeric Hydrogel as Sensing Units

Issues of Stabilization of Particles of Liquid-Crystalline Dispersions

Immobilization of DNA LCD Particles in a Hydrogel

Formation and Immobilization of DNA Nanoconstruction in a Hydrogel

About the Authors

Chemists, physicists, molecular biologists, and other scientists and students of related fields.

About the Series

Liquid Crystals Book Series

The Liquid Crystals Book Series publishes authoritative accounts of all aspects of the field, ranging from the basic fundamentals to the forefront of research, from the physics of liquid crystals to their chemical and biological properties, and from their self-assembling structures to their applications in devices. The series provides readers new to liquid crystals with a firm grounding in the subject, while offering experienced scientists and liquid crystallographers an indispensable resource to enhance their own research.

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
SCI010000
SCIENCE / Biotechnology
SCI013060
SCIENCE / Chemistry / Industrial & Technical
SCI055000
SCIENCE / Physics