487 pages | 12 Color Illus. | 57 B/W Illus.
The recent introduction of nanomedicines in the drug therapy arena is revolutionizing the management of severe diseases. The key advance in the field is the optimization of the biological fate of drug molecules, thus improving the therapeutic effect while keeping to a very minimum the associated toxicity. Volume one of this book series, Nanoplatforms in Drug Delivery, established the basic aspects in the development of drug-loaded nanoplatforms, the so-called nanomedicines or nanodrugs, focusing on representative materials and strategies used in their formulation.
Taking advantage of the advanced conceptualizations on nanomedicine engineering that were described in volume one, volume two, Nano-Engineering Strategies and Nanomedicines against Severe Diseases, analyzes in depth special features related to the formulation of nanoplatforms for oral, dental, topical and transdermal, pulmonary and nasal, ocular and otic, vaginal, and brain drug delivery and targeting. Particular aspects of nanomedicine engineering and in vivo fate associated with the routing of drug administration are given special attention. In addition, an up-to-date view is presented on the use of nanomedicines against severe diseases, such as cancer, cardiovascular diseases, neurodegenerative disorders, infectious diseases, chronic inflammatory diseases, and metabolic diseases. The chapters analyze the key factors that need to be controlled to achieve the optimum therapeutic effect. Attention is further given to gene delivery and the recent concept of nanotheranosis.
Preface to the Book Series; José L. Arias
Preface to Volume 2; José L. Arias
Emerging Technologies of Polymers for Nanomedicine Applications; Tatiana Andreani, Nagasamy Venkatesh, Sandra V. Ferreira, Amélia M. Silva and Eliana B. Souto
Nanotechnology for Oral Drug Delivery and Targeting; Catarina Pinto Reis, Nuno Martinho and Christiane Damgé
Nanoparticulate Systems for Dental Drug Delivery; Sanko Nguyen, Gro Smistad, Morten Rykke and Marianne Hiorth
Nanotechnology for Topical and Transdermal Drug Delivery and Targeting; Elizabeth Ryan, Jeff Grice and Michael S Roberts
Nanotechnology for Pulmonary and Nasal Drug Delivery; Helene L. Dugas and Robert O. Williams III
Lipid Nanoplatforms for Pulmonary Drug Delivery; B.M. Ponte, I.S. Santos, Ana S. Macedo and Eliana B. Souto
Nanotechnology for Ocular and Otic Drug Delivery and Targeting; Anthony A. Attama, Charles Lovelyn and Ebele B. Onuigbo
Nanotechnology for Vaginal Drug Delivery and Targeting; Mazen El-Hammadi and José L. Arias
Potential Nanocarriers for Brain Drug Delivery; Mª Ángeles Holgado, José L. Venero, Josefa Álvarez-Fuentes, Mercedes Fernández-Arévalo and Lucia Martín-Banderas
Nanomaterials and Cancer Therapy; Laura Cabeza, Gloria Perazzoli, Raúl Ortiz, Octavio Caba, Pablo A. Álvarez, Consolación Melguizo, José C. Prados and Antonia Aránega
Nanomedicine in Cardiovascular Disease; Costas Psarros, Regent Lee, Alexios Antonopoulos, Marios Margaritis and Charalambos Antoniades
Nano(Neuro)Medicinal Interventions for Neurodegenerative Disorders: a Meta-Analysis of Concurrent Challenges and Strategic Solutions; Viness Pillay, Pradeep Kumar, Girish Modi and Yahya E. Choonara
Nanomedicines against Infectious Diseases; Leticia H. Higa, Ana Paula Perez, Priscila Schilrreff, Maria Jose Morilla and Eder Lilia Romero
Nanomedicines against Chronic Inflammatory Diseases; Mazen El-Hammadi and José L. Arias
Nanomedicine Biopharmaceuticals for Metabolic Diseases; Filipa Antunes and Bruno Sarmento
Nanotechnology in Gene Knockdown and miRNA Replacement in Vivo; Achim Aigner
Nanotheranostics; Benjamin Theek, Sijumon Kunjachan, Fabian Kiessling and Twan Lammers