The applications of nanoparticulate drug delivery have gained significant attention in cancer diagnosis and treatment. Owing to their unique features and design, nanomedicines have made remarkable progress in eliminating dreadful tumors. Research in cancer nanomedicine spans multitudes of drug-delivery systems that include high tumor-targeting ability, sensitivity toward tumor microenvironments, and improved efficacy. Various nanocarriers have been developed and approved for anti-tumor drug targeting. These nanocarriers, such as liposomes, micelles, nanotubes, dendrimers, and peptides, offer several advantages including high selectivity, multifunctionality, specificity, biocompatibility, and precise control of drug release. This book provides complete information about each aspect of nanomaterials and nanotherapeutics, including synthesis, analysis, disease diagnosis, mechanistic insight, targeted drug delivery, and clinical implications in a concise and informative way. It presents simple and reader-friendly representations of the mechanisms of action of nanomaterials on cellular targets and highlights the challenges in targeted drug delivery with ongoing chemotherapeutic drugs.
Table of Contents
1. Introduction to Nanotherapeutics: A Synthetic Preview
Nahid Rehman and Anjana Pandey
2. Synthesis, Characterization, and Application of Metal Oxide Nanoparticles
Ashutosh Dixit, Renu Bala, and Vivek Sheel Jaswal
3. Current Scenario of Nanomaterials in Cancer Diagnostics
4. Emerging Antineoplastic Potential of Nanoparticles Against Different Types of Cancer
Vivek Kumar Garg, Abhilasha Sood, Deepika Kapoor, et al.
5. Nanomaterials-Mediated Oxidative Stress in Cancer: Recent Trends and Future Perspectives
Tuğba Ören Varol and Mehmet Varol
6. Role of Nanotherapeutics in Inhibiting Cancer Angiogenesis: A Novel Perspective
Neha Atale and Vibha Rani
7. Inhibition of Cancer Cell Metastasis by Nanotherapeutics: Current Achievements and Future Trends
Hemant Joshi, Gaurav Kumar, Hardeep Singh Tuli, and Sonam Mittal
8. Nanotherapeutics as Potential Carriers for the Delivery of Anticancer Drugs
Ruchira Joshi, Priyanka Shah, Hardeep Singh Tuli, and Ginpreet Kaur
9. Nanoparticle-Associated Toxicity and Concept of Edible Nanoparticles: Promising Therapeutics in Near Future
Priyanka Shah, Ruchira Joshi, Onkar Nigade, et al.
Hardeep Singh Tuli is an assistant professor at the Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, India. He has also been a lecturer at the Department of Applied Sciences, Institute of Science and Technology, Klawad, Yamunanagar, India. He has served as a reviewer for several international journals and a guest editor for the journal Frontiers in Pharmacology. He has more than 10 years of teaching and research experience in pharmacology, mammalian physiology, and natural products. Dr. Tuli has published more than 80 papers in peer-reviewed international journals, authored several book chapters, and edited three international books on natural products and chemoprevention. He has been placed in the top 2% of highly cited researchers in the world in the pharmacology area. His research is focused on the isolation, characterization, and biochemical evaluation of natural metabolites as anticancer agents.