Natural Immunity to Normal Hemopoietic Cells presents the first comprehensive compilation of experimental systems, theories, and views of the mechanisms behind NK cell recognition of normal hemopoietic cells. Leading scientists in the field have contributed chapters covering the role of Major Histocompatibility Complex (MHC) class I antigen expression of target cells in NK cell recognition, descriptions of NK allospecificities controlled by the MHC, and the role of alloreactive T cells and NK cells in acute bone marrow allograft rejection. Controversies between different theories are discussed in a balanced manner to convey a complete picture of the "state of the art." References give comprehensive, updated lists of current and previous research publications on this topic. The book is essential for immunologists, hematologists, clinical bone marrow transplantation researchers, and other scientists and students interested in recognition mechanisms of the immune system and the role of the MHC.
Table of Contents
Allogeneic Lymphocyte Cytotoxicity (ALC) in Rats: Allogeneic Recognition Versus Failed Self Recognition (B.F. Heslop). Bone Marrow Transplantation and Natural Killer Cells in Mice (M. Bennett, R.M. Rembecki, C.L. Sentman, W.J. Murphy, Y.Y. Lawrence Yu, C. Davenport, and V. Kumar). Murine F1 Hybrid Anti-Parent Reactivities in NK Cells and T Lymphocytes (I. Nakamura, V.K. Milisauskas, and M.J. Kirisits). Alloreactive Rat Natural Killer (NK) Cells In Vivo and In Vitro: The Role of the Major Histocompatibility Complex (MHC) (B. Rolstad, K. Wonigeit, and J.T. Vaage). Mechanisms of Acute Marrow Graft Rejection in Murine Model Systems (G. Dennert and M. Nowicki). Influence of MHC Class I Molecules on Natural Killer Cell Repertoire and Target Cell Sensitivity (P. Høglund, H.-G. Ljunggren, and K. Kärre). Specific Functions and Receptors of Human NK Cells (L. Moretta, E. Ciccone, and A. Moretta).